ArticleMuscle & nerve2011
Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications.
Article in Muscle & nerve, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01702987 (Evaluation of Ubiquinol on the Association of Statins and Mitochondrial Oxidative Capacity Using 31P Magnetic Resonance Imaging), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Ubiquinol on the Association of Statins and Mitochondrial Oxidative Capacity Using 31P Magnetic Resonance Imaging
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.JACC. Heart failure · 2016Trial
- Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy.Translational research : the journal of laboratory and clinical medicine · 2015Trial
- Simvastatin impairs exercise training adaptations.Journal of the American College of Cardiology · 2013 · on this mapTrial
- Effect of statins on skeletal muscle function.Circulation · 2013 · on this mapTrial
- Simultaneous Assessment of Skeletal Muscle Energetics and Blood Flow During Dynamic Exercise by InterleavedMagnetic resonance in medicine · 2026Article
- Article
- Mechanisms and effects of metformin on skeletal muscle disorders.Frontiers in neurology · 2023Review
- The impact of statin therapy and aerobic exercise training on skeletal muscle and whole-body aerobic capacity.American heart journal plus : cardiology research and practice · 2021Article
- Effects of statins on mitochondrial pathways.Journal of cachexia, sarcopenia and muscle · 2021Review
- Statin-Associated Muscle Disease: Advances in Diagnosis and Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.Scientific reports · 2018Observational
- Management of Statin Intolerance in 2018: Still More Questions Than Answers.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2018Review
- Skeletal muscle metabolic adaptations to endurance exercise training are attainable in mice with simvastatin treatment.PloS one · 2017Article
- Article
- Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization.American journal of physiology. Heart and circulatory physiology · 2015Review
- Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.European heart journal · 2015Review
- Treatment of dyslipidemia with statins and physical exercises: recent findings of skeletal muscle responses.Arquivos brasileiros de cardiologia · 2015Review
- Statins and physical activity in older men: the osteoporotic fractures in men study.JAMA internal medicine · 2014Article
- High cytochrome c oxidase expression links to severe skeletal energy failure by (31)P-MRS spectroscopy in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes.CNS neuroscience & therapeutics · 2014Article
- Phosphorus Spectroscopy of Calf Muscles before and after Exercise.Polish journal of radiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Muscle pain is a common side effect of statin medications, but the cause is poorly understood. We characterized phosphocreatine (PCr) exercise recovery kinetics in 10 patients with hypercholesterolemia before and after a 4-week regimen of statin therapy using 31-phosphorus magnetic resonance spectroscopy ((31) P-MRS). (31) P spectra were obtained before, during, and after exercise on a calf flexion pedal ergometer. Creatine kinase (CK) serum levels were drawn before and after statin therapy. The mean metabolic recovery time constant in subjects increased from 28.1 s (SE = 6.5 s) to 55.4 s (SE = 7.4 s) after statin therapy. The unweighted mean of the pre/post-recovery time difference was -27.3 s (SE = 12.4 s; P = 0.02). Pre- and post-therapy CK levels were not significantly different (P = 0.50). Metabolic recovery time in the calf is prolonged in patients after statin use. This suggests that statins impair mitochondrial oxidative function, and (31) P MRS is a potential study model for statin-associated myopathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.