Evidence map›Paper›PMID 21170739›Full record

ArticleImmunologic research2011

Impaired pulmonary immunity post-bone marrow transplant.

Stephanie M Coomes, Leah L N Hubbard, Bethany B Moore

Open access · greenAbstract read
In one paragraph

Article in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.American journal of respiratory and critical care medicine · 2018
    Article
  4. Review
  5. Prostaglandin EPharmacology & therapeutics · 2018
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Stephanie M CoomesGraduate Program in Immunology, University of Michigan, Ann Arbor, 48109-2200, USA.
Leah L N Hubbard
Bethany B Moore
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
PGE2 Regulation of Host Defense post-BMTR01AI065543 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOORE, BETHANY B. · 2007 to 2011
$1.9M
HSCT-induced changes that impair lung innate immunityR56AI065543 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOORE, BETHANY B. · 2012 to 2012
$363k
NIAID NIH HHS AI065543NIAID NIH HHS R01 AI065543NIAID NIH HHS R56 AI065543NIAID NIH HHS T32 AI007413
6 · The paper itself

Abstract

Infectious complications are a serious cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT), and the lung is a particular target organ post-transplant. Our laboratory has used a murine bone marrow transplant model to study alterations in immunity that occur as a result of transplantation. Our studies focus on immune responses that occur following immune cell reconstitution in the absence of immunosuppressive drug therapy or graft-versus-host disease. We have found that impaired clearance of both bacterial and viral pulmonary infections is related to specific alterations in immune cell function and cytokine production. Our data offer insight into mechanisms that contribute to opportunistic infections in HSCT recipients.

Indexed as

AnimalsBone Marrow TransplantationDisease Models, AnimalHematopoietic Stem Cell TransplantationHumansImmunity, InnateLung DiseasesMiceOpportunistic InfectionsPneumonia, ViralPseudomonas aeruginosaPseudomonas InfectionsT-LymphocytesViruses

Identifiers

PMID21170739
PMCPMC3310400
OpenAlexW1997710419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.