Evidence map›Paper›PMID 21170694›Full record

SynthesisWiener medizinische Wochenschrift (1946)2010

Ginkgo biloba in Alzheimer's disease: a systematic review.

Inger M Janssen, Sibylle Sturtz, Guido Skipka, Annette Zentner, Marcial Velasco Garrido, Marcial V Garrido, Reinhard Busse

Erratum issuedAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Wiener medizinische Wochenschrift (1946), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Dementia.BMJ clinical evidence · 2012
    Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Current issues in molecular biology · 2023
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Cytotoxic effect ofHeliyon · 2020
    Article
  13. Review
  14. Review
  15. Article
  16. Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.International review of cell and molecular biology · 2018
    Review
  17. Review
  18. Article
  19. Article
  20. An Overview of Systematic Reviews ofFrontiers in aging neuroscience · 2016
    Review
4 · The record

Corrections and comments

  • Erratum issued
    Garrido, Marcial V [corrected to Velasco Garrido, Marcial]
5 · Who and what money

Authors and funding

7 authors.

Inger M JanssenInstitute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany. inger.janssen@iqwig.de
Sibylle Sturtz
Guido Skipka
Annette Zentner
Marcial Velasco Garrido
Marcial V Garrido
Reinhard Busse

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review determines the benefit of treatment with Ginkgo biloba (Ginkgo) in Alzheimer's disease (AD) concerning patient-relevant outcomes. Bibliographic databases, clinical trial and study result registries were searched for randomized controlled trials (RCTs) in patients with AD (follow-up ≥16 weeks) comparing Ginkgo to placebo or a different treatment option. Manufacturers were asked to provide unpublished data. If feasible, data were pooled by meta-analysis. Six studies were eligible; overall, high heterogeneity was shown for most outcomes, except safety aspects. Among studies administering high-dose Ginkgo (240 mg), all studies favour treatment though effects remain heterogeneous. In this subgroup, a benefit of Ginkgo exists for activities of daily living. Cognition and accompanying psychopathological symptoms show an indication of a benefit. A harm of Ginkgo is not evident. An estimation of the effect size was not possible for any outcome. Further evidence is needed which focuses especially on subgroups of AD patients.

Indexed as

PhytotherapyAlzheimer DiseaseDose-Response Relationship, DrugGinkgo bilobaGinkgo ExtractHumansNootropic AgentsPlant ExtractsRandomized Controlled Trials as TopicTreatment OutcomeGinkgo biloba extractGinkgo ExtractNootropic AgentsPlant Extracts

Identifiers

PMID21170694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.