ArticlePloS one2010
Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Extracorporeal Photopheresis: Secreted Factors That Promote Immunomodulation.Transplantation direct · 2025Article
- Human type 1 conventional dendritic cells contribute to skin transplant rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Dual roles ofFrontiers in immunology · 2025Article
- HSP70 and Primary Arterial Hypertension.Biomolecules · 2023Review
- Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes.Frontiers in immunology · 2021Review
- The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum.Advances in experimental medicine and biology · 2021Article
- Review
- Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model.The Kaohsiung journal of medical sciences · 2020Article
- March1-dependent modulation of donor MHC II on CD103Nature communications · 2018Article
- Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Danger signals in regulating the immune response to solid organ transplantation.The Journal of clinical investigation · 2017Review
- Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance.Journal of leukocyte biology · 2017Article
- The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins.Frontiers in immunology · 2017Review
- New strategy for testing efficacy of immunotherapeutic compounds for diabetes in vitro.BMC biotechnology · 2016Article
- Tolerization against atherosclerosis using heat shock protein 60.Cell stress & chaperones · 2016Review
- Modulation of Alloimmunity by Heat Shock Proteins.Frontiers in immunology · 2016Review
- Mechanisms and consequences of injury and repair in older organ transplants.Transplantation · 2014Article
- Article
- Role of Fused Mycobacterium tuberculosis Immunogens and Adjuvants in Modern Tuberculosis Vaccines.Frontiers in immunology · 2014Review
- Heat shock proteins and regulatory T cells.Autoimmune diseases · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeat shock proteins (Hsps) are stress induced proteins with immunomodulatory properties. The Hsp70 of Mycobacterium tuberculosis (TBHsp70) has been shown to have an anti-inflammatory role on rodent autoimmune arthritis models, and the protective effects were demonstrated to be dependent on interleukin-10 (IL-10). We have previously observed that TBHsp70 inhibited maturation of dendritic cells (DCs) and induced IL-10 production by these cells, as well as in synovial fluid cells. METHODOLOGY/PRINCIPAL
findingsWe investigated if TBHsp70 could inhibit allograft rejection in two murine allograft systems, a transplanted allogeneic melanoma and a regular skin allograft. In both systems, treatment with TBHsp70 significantly inhibited rejection of the graft, and correlated with regulatory T cells (Tregs) recruitment. This effect was not tumor mediated because injection of TBHsp70 in tumor-free mice induced an increase of Tregs in the draining lymph nodes as well as inhibition of proliferation of lymph node T cells and an increase in IL-10 production. Finally, TBHsp70 inhibited skin allograft acute rejection, and depletion of Tregs using a monoclonal antibody completely abolished this effect. CONCLUSIONS/SIGNIFICANCE: We present the first evidence for an immunosuppressive role for this protein in a graft rejection system, using an innovative approach--immersion of the graft tissue in TBHsp70 solution instead of protein injection. Also, this is the first study that demonstrates dependence on Treg cells for the immunosuppressive role of TBHsp70. This finding is relevant for the elucidation of the immunomodulatory mechanism of TBHsp70. We propose that this protein can be used not only for chronic inflammatory diseases, but is also useful for organ transplantation management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.