ArticleThe Journal of clinical investigation1990
Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 70 citations in OpenAlex.
- Gastrin and the Moderate Hypergastrinemias.International journal of molecular sciences · 2021Review
- Cholecystokinin and the hormone concept.Endocrine connections · 2021Review
- Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.Journal of the American Heart Association · 2017Review
- Cholecystokinin-From Local Gut Hormone to Ubiquitous Messenger.Frontiers in endocrinology · 2017Review
- In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.Protein and peptide letters · 2009Review
- The endoproteolytic maturation of progastrin and procholecystokinin.Journal of molecular medicine (Berlin, Germany) · 2006Review
- Cleavage of arginyl-arginine and lysyl-arginine from the C-terminus of pro-hormone peptides by human germinal angiotensin I-converting enzyme (ACE) and the C-domain of human somatic ACE.The Biochemical journal · 1997Article
- Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel post-translational processing mechanism.The EMBO journal · 1995Article
- Human seminal plasma contains somatostatin-64.The Biochemical journal · 1994Article
- Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
In previous studies we have shown that the gene encoding cholecystokinin (CCK) is expressed in spermatogenic cells of several mammalian species. In the present study we show that a gene homologous to the CCK-related hormone, gastrin, is expressed in the human testis. The mRNA hybridizing to a human gastrin cDNA probe in the human testis was of the same size (0.7 kb) as gastrin mRNA in the human antrum. By in situ hybridization the gastrinlike mRNA was localized to seminiferous tubules. Immunocytochemical staining of human testis revealed gastrinlike peptides in the seminiferous tubules primarily at a position corresponding to spermatids and spermatozoa. In ejaculated spermatozoa gastrinlike immunoreactivity was localized to the acrosome. Acrosomal localization could also be shown in spermatids with electron microscopy. Extracts of the human testis contained significant amounts of progastrin, but no bioactive amidated gastrins. In contrast, ejaculated sperm contained mature carboxyamidated gastrin 34 and gastrin 17. The concentration of gastrin in ejaculated human spermatozoa varied considerably between individuals. We suggest that amidated gastrin (in humans) and CCK (in other mammals) are released during the acrosome reaction and that they may be important for fertilization.
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Registered trials
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