ArticleActa pharmacologica Sinica2011
Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma.
Article in Acta pharmacologica Sinica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Inhaled corticosteroids do not reduce initial high activity of matrix metalloproteinase (MMP)-9 in exhaled breath condensates of children with asthma exacerbation: a proof of concept study.Central-European journal of immunology · 2016Article
- Prolonged Treatment with Inhaled Corticosteroids does not Normalize High Activity of Matrix Metalloproteinase-9 in Exhaled Breath Condensates of Children with Asthma.Archivum immunologiae et therapiae experimentalis · 2015Article
- Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.American journal of respiratory and critical care medicine · 2015Article
- Assessment of second-line treatments for patients with uncontrolled moderate asthma.International journal of clinical and experimental medicine · 2015Article
- Risk factors related to persistent airflow obstruction in severe asthma in Chinese Han population.International journal of clinical and experimental medicine · 2014Article
- Airway remodelling in asthma: role for mechanical forces.Asia Pacific allergy · 2014Review
- Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic.The Korean journal of internal medicine · 2011Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma.
methodsThirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.5/160 μg twice daily for one year. The effect of formoterol-budesonide on airway remodeling was assessed with comparing high-resolution computer tomography (HRCT) images of asthmatic patients and controls, as well as expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness.
resultsThe differences in age and gender between the two groups were not significant. However, differences in FVC %pred, FEV(1) %pred, and PC(20) between the two groups were significant. After treatment with formoterol-budesonide, the asthma patients' symptoms were relieved, and their lung function was improved. The WT and WA% of HRCT images in patients with asthma was increased, whereas treatment with formoterol-budesonide caused these values to decrease. The expression of MMP-9, TIMP-1, and TGF-β(1) in induced sputum samples increased in patients with asthma and decreased dramatically after treatment with formoterol-budesonide. The WT and WA% are correlated with the expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness, while these same values are correlated negatively with FEV(1)/FVC and FEV(1)%.
conclusionFormoterol-budesonide might interfere in chronic inflammation and airway remodeling in asthmatic patients. HRCT can be used to effectively evaluate airway remodeling in asthmatic patients.
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