ArticleNature neuroscience2011
Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
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- Mechanisms involved in corticotropin-releasing factor-induced excitation of entorhinal neurons and facilitation of glutamate release at the perforant pathway.Journal of neurophysiology · 2025Article
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation Therapy Programming.Journal of pain research · 2025Article
- Membrane potential states gate synaptic consolidation in human neocortical tissue.Nature communications · 2024Article
- Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.Cells · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
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- Unitary synaptic responses of parvalbumin interneurons evoked by excitatory neurons in the mouse barrel cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- L-type CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function.Cell reports · 2021Article
- Fluorescence lifetime imaging reveals regulation of presynaptic CaJournal of neurochemistry · 2021Article
- Anodal transcranial direct current stimulation increases corticospinal excitability, while performance is unchanged.PloS one · 2021Article
- Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding.PLoS computational biology · 2020Article
- Differentially poised vesicles underlie fast and slow components of release at single synapses.The Journal of general physiology · 2020Article
- Axonal NaScience advances · 2020Article
- Background calcium induced by subthreshold depolarization modifies homosynaptic facilitation at a synapse in Aplysia.Scientific reports · 2020Article
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- EGTA Can Inhibit Vesicular Release in the Nanodomain of Single CaFrontiers in synaptic neuroscience · 2019Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
In many neurons, subthreshold somatic depolarization can spread electrotonically into the axon and modulate subsequent spike-evoked transmission. Although release probability is regulated by intracellular Ca(2+), the Ca(2+) dependence of this modulatory mechanism has been debated. Using paired recordings from synaptically connected molecular layer interneurons (MLIs) of the rat cerebellum, we observed Ca(2+)-mediated strengthening of release following brief subthreshold depolarization of the soma. Two-photon microscopy revealed that, at the axon, somatic depolarization evoked Ca(2+) influx through voltage-sensitive Ca(2+) channels and facilitated spike-evoked Ca(2+) entry. Exogenous Ca(2+) buffering diminished these Ca(2+) transients and eliminated the strengthening of release. Axonal Ca(2+) entry elicited by subthreshold somatic depolarization also triggered asynchronous transmission that may deplete vesicle availability and thereby temper release strengthening. In this cerebellar circuit, activity-dependent presynaptic plasticity depends on Ca(2+) elevations resulting from both sub- and suprathreshold electrical activity initiated at the soma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.