ArticleNature cell biology2011
Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.
Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Quantitative imaging of RNA polymerase II activity in plants reveals the single-cell basis of tissue-wide transcriptional dynamics.Nature plants · 2021Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis.Molecular systems biology · 2018Article
- Seeing is believing: the Bicoid protein reveals its path.Hereditas · 2018Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
- Probing the impact of temperature on molecular events in a developmental system.Scientific reports · 2015Article
- Fundamental origins and limits for scaling a maternal morphogen gradient.Nature communications · 2015Article
- Messages do diffuse faster than messengers: reconciling disparate estimates of the morphogen bicoid diffusion coefficient.PLoS computational biology · 2014Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- The Interplay between Autophagy and Aging.Diabetes & metabolism journal · 2013Review
- The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation.Molecular biology of the cell · 2013Article
- Comparative approaches to the study of physiology: Drosophila as a physiological tool.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo.PloS one · 2013Article
- Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.Nature communications · 2013Article
- mRNA localization and translational control in Drosophila oogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs.Physical biology · 2012Article
- Drosophila Bicoid is a substrate of sumoylation and its activator function is subject to inhibition by this post-translational modification.FEBS letters · 2012Article
- Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts.Bioinformatics (Oxford, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bicoid (Bcd) is a morphogenetic protein that instructs patterning along the anterior-posterior (A-P) axis in Drosophila melanogaster embryos. Despite extensive studies, what controls the formation of a normal concentration gradient of Bcd remains an unresolved and controversial question. Here, we show that Bcd protein degradation is mediated by the ubiquitin-proteasome pathway. We have identified an F-box protein, encoded by fates-shifted (fsd), that has an important role in Bcd protein degradation by targeting it for ubiquitylation. Embryos from females lacking fsd have an altered Bcd gradient profile, resulting in a shift of the fatemap along the A-P axis. Our study is an experimental demonstration that, contrary to an alternative hypothesis, Bcd protein degradation is required for normal gradient formation and developmental fate determination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.