ReviewCurrent opinion in rheumatology2011
Crystals, inflammation, and osteoarthritis.
Review in Current opinion in rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 84 citations in OpenAlex.
- Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint.Molecular and cellular biochemistry · 2017Trial
- Ultrasonography in the assessment of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up.Annals of the rheumatic diseases · 2025Observational
- An objective diagnosis of gout and calcium pyrophosphate deposition disease with machine learning of Raman spectra acquired in a point-of-care setting.Rheumatology (Oxford, England) · 2025Article
- Synovial fluid dual-biomarker algorithm accurately differentiates osteoarthritis from inflammatory arthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Interplay of calcium pyrophosphate crystals, oxidative stress, and clinical features on knee osteoarthritis severity.Clinical rheumatology · 2025Article
- Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.Pain · 2024Article
- Sterile osteomyelitis: a cardinal sign of autoinflammation.Reumatologia · 2024Review
- Titanium Dioxide Promotes the Growth and Aggregation of Calcium Phosphate and Monosodium Urate Mixed Crystals.Crystals · 2024Article
- Synovial Fluid from Patients with Osteoarthritis Shows Different Inflammatory Features Depending on the Presence of Calcium Pyrophosphate Crystals.International journal of molecular sciences · 2023Article
- Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway.Biomedicines · 2023Review
- Arthroscopic Implantation of Adipose-Derived Stromal Vascular Fraction Improves Cartilage Regeneration and Pain Relief in Patients With Knee Osteoarthritis.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Ablation of TRPC3 disrupts CaScientific reports · 2023Article
- Review
- Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention.Biomedicines · 2022Review
- Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes.International journal of molecular sciences · 2022Article
- Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems.Advanced therapeutics · 2021Article
- Degenerative osteoarthritis a reversible chronic disease.Regenerative therapy · 2020Review
- The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature.Frontiers in medicine · 2020Review
- An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis.Seminars in immunopathology · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewCalcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals are common components of osteoarthritic joint fluids and tissues. Why these crystals form and how they contribute to joint damage in osteoarthritis remain unclear. With renewed interest in inflammation as a key component of osteoarthritis the role of calcium-containing crystals in this common disease warrants re-examination. RECENT
findingsThere is ample evidence supporting a pathogenic role for inflammation in osteoarthritis, and the innate immune system likely participates in this inflammatory process. Recent work reinforces the almost universal existence of calcium-containing crystals in tissues from patients with end-stage osteoarthritis. Calcium-containing crystals may contribute to inflammation in osteoarthritis tissues through their direct interactions with components of the innate immune system, as well as by inducing or amplifying other inflammatory signals. SUMMARY: There is increasing evidence that calcium-containing crystals contribute to osteoarthritis and their inflammatory properties may mediate detrimental effects through innate immunity signals. Calcium-containing crystals may thus represent important therapeutic targets in osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.