Evidence map›Paper›PMID 21169836›Full record

ReviewCurrent opinion in pediatrics2011

The new bronchopulmonary dysplasia.

Alan H Jobe

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03961139 (Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effects on Respiratory Morbidity), which is not on this map. Cited by 245 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 7 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03961139 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effects on Respiratory Morbidity: A Multicentre Randomised Controlled Clinical Trial

TypeinterventionalSponsorNational University Hospital, SingaporeRan2019 to 2022Enrolled150ConditionsChronic Lung Disease of Prematurity, Bronchopulmonary DysplasiaArmsMethod of feeding, continuous feeding OR bolus feeding
3 · Its place in the literature

Who cites it

245 citing papers in PubMed, 7 syntheses or guidelines pooled it, 581 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants.Journal of perinatology : official journal of the California Perinatal Association · 2014
    Pooled it
  8. Trial
  9. Trial
  10. Randomised trial of azithromycin to eradicateArchives of disease in childhood. Fetal and neonatal edition · 2020
    Trial
  11. Trial
  12. Trial
  13. Placental transfusion in preterm neonates of 30-33 weeks' gestation: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Trial
  14. Inhaled hydrofluoalkane-beclomethasone dipropionate in bronchopulmonary dysplasia. A double-blind, randomized, controlled pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Trial
  15. Article
  16. Review
  17. Review
  18. Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  19. Article
  20. Article

185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alan H JobeCincinnati Children's Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA. alan.jobe@cchmc.org
Cincinnati Children's Hospital Medical Center · US

Funding

NEW MEDIATORS OF CLINICAL LUNG MATURATIONR01HL065397 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI JOBE, ALAN H · 2000 to 2007
$2.8M
Biomarkers of Immunologic Function and Preterm Respiratory OutcomesU01HL101800 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A., JOBE, ALAN H · 2010 to 2014
$2.5M
Late Preterm Birth, Ureaplasma Species and Childhood Lung DiseaseR01HL097064 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI JOBE, ALAN H, KALLAPUR, SUHAS · 2009 to 2012
$2.0M
NHLBI NIH HHS HL101800NHLBI NIH HHS HL97064NHLBI NIH HHS R01 HL065397NHLBI NIH HHS R01 HL097064NHLBI NIH HHS U01 HL101800
6 · The paper itself

Abstract

purpose of reviewBronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment. RECENT

findingsThe epidemiology of BPD continues to demonstrate that birth weight and gestational age are most predictive of BPD. Correlations of BPD with chorioamnionitis are clouded by the complexity of the fetal exposures to inflammation. Excessive oxygen use in preterm infants can increase the risk of BPD but low saturation targets may increase death. Numerous recent trials demonstrate that many preterm infants can be initially stabilized after delivery with continuous positive airway response (CPAP) and then be selectively treated with surfactant for respiratory distress syndrome. The growth of the lungs of the infant with BPD through childhood remains poorly characterized. SUMMARY: Recent experiences in neonatology suggest that combining less invasive care strategies that avoid excessive oxygen and ventilation, decrease postnatal infections, and optimize nutrition may decrease the incidence and severity of BPD.

Indexed as

Bronchopulmonary DysplasiaChorioamnionitisFemaleHumansInfant, NewbornInfant, PrematureMultipotent Stem CellsNitric OxideOxygen Inhalation TherapyPregnancyRespiration, ArtificialNitric Oxide

Identifiers

PMID21169836
PMCPMC3265791
OpenAlexW2025283490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.