Evidence map›Paper›PMID 21169695›Full record

ArticleJournal of synchrotron radiation2011

Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi.

Keishi Yamaguchi, Naoki Okamoto, Keiji Tokuoka, Shigeru Sugiyama, Nahoko Uchiyama, Hiroyoshi Matsumura, Koji Inaka, Yoshihiro Urade, Tsuyoshi Inoue

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of synchrotron radiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Plants (Basel, Switzerland) · 2025
    Article
  2. Old Yellow Enzyme fromFrontiers in immunology · 2018
    Article
  3. Review
  4. Bioactive lipids in Trypanosoma cruzi infection.Advances in parasitology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Keishi YamaguchiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamada-Oka 2-1, Suita, Osaka 565-0871, Japan.
Naoki Okamoto
Keiji Tokuoka
Shigeru Sugiyama
Nahoko Uchiyama
Hiroyoshi Matsumura
Koji Inaka
Yoshihiro Urade
Tsuyoshi Inoue
Osaka University · JPMaruwa Foods and Biosciences (Japan) · JPNational Institute of Health Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2α) production specifically.

Indexed as

Binding SitesCrystallography, X-RayFlavin MononucleotideHydroxyprostaglandin DehydrogenasesModels, MolecularNADPH DehydrogenaseTrypanosoma cruziVitamin K 3Flavin MononucleotideHydroxyprostaglandin DehydrogenasesNADPH Dehydrogenaseprostaglandin-F synthaseVitamin K 3

Identifiers

PMID21169695
PMCPMC3004258
OpenAlexW2140781354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.