ArticleThe Journal of biological chemistry2011
MMS6 protein regulates crystal morphology during nano-sized magnetite biomineralization in vivo.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 188 citations in OpenAlex.
- Elucidation of the aragonite nanofiber formation mechanism of LICP contained in the hinge ligament ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cross-linking proteomics analysis for reliable identification of MamXY-associated magnetosome formation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Understanding microbial biomineralization at the molecular level: recent advances.World journal of microbiology & biotechnology · 2024Review
- Intrinsic and extrinsic determinants of conditional localization of Mms6 to magnetosome organelles inJournal of bacteriology · 2024Article
- Biominerals and Bioinspired Materials in Biosensing: Recent Advancements and Applications.International journal of molecular sciences · 2024Review
- Nitric oxide sensor NsrR is the key direct regulator of magnetosome formation and nitrogen metabolism in Magnetospirillum.Nucleic acids research · 2024Article
- Biomedical applications of magnetosomes: State of the art and perspectives.Bioactive materials · 2023Review
- Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles.Biosensors · 2022Review
- The Magnetosome Protein, Mms6 fromInternational journal of molecular sciences · 2022Article
- Mineralogy of Bioprecipitate Evolution over Induction Times Mediated by Halophilic Bacteria under Various Mg/Ca Molar Ratios.ACS omega · 2022Article
- Biogeochemical fingerprinting of magnetotactic bacterial magnetite.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Potential and whole-genome sequence-based mechanism of elongated-prismatic magnetite magnetosome formation in Acidithiobacillus ferrooxidans BYM.World journal of microbiology & biotechnology · 2022Article
- Adsorption of Biomineralization Protein Mms6 on Magnetite (FeInternational journal of molecular sciences · 2022Article
- A protease-mediated switch regulates the growth of magnetosome organelles inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Learning from magnetotactic bacteria:Frontiers in cellular neuroscience · 2022Article
- Bioinspired Magnetic Nanochains for Medicine.Pharmaceutics · 2021Review
- Folding of an Intrinsically Disordered Iron-Binding Peptide in Response to Sedimentation Revealed by Cryo-EM.Journal of the American Chemical Society · 2020Article
- Expanding magnetic organelle biogenesis in the domain Bacteria.Microbiome · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomineralization, the process by which minerals are deposited by organisms, has attracted considerable attention because this mechanism has shown great potential to inspire bottom-up material syntheses. To understand the mechanism for morphological regulation that occurs during biomineralization, many regulatory proteins have been isolated from various biominerals. However, the molecular mechanisms that regulate the morphology of biominerals remain unclear because there is a lack of in vivo evidence. Magnetotactic bacteria synthesize intracellular magnetosomes that comprise membrane-enveloped single crystalline magnetite (Fe(3)O(4)). These nano-sized magnetite crystals (<100 nm) are bacterial species dependent in shape and size. Mms6 is a protein that is tightly associated with magnetite crystals. Based on in vitro experiments, this protein was first implicated in morphological regulation during nano-sized magnetite biomineralization. In this study, we analyzed the mms6 gene deletion mutant (Δmms6) of Magnetospirillum magneticum (M. magneticum) AMB-1. Surprisingly, the Δmms6 strain was found to synthesize the smaller magnetite crystals with uncommon crystal faces, while the wild-type and complementation strains synthesized highly ordered cubo-octahedral crystals. Furthermore, deletion of mms6 gene led to drastic changes in the profiles of the proteins tightly bound to magnetite crystals. It was found that Mms6 plays a role in the in vivo regulation of the crystal structure to impart the cubo-octahedral morphology to the crystals during biomineralization in magnetotactic bacteria. Magnetotactic bacteria synthesize magnetite crystals under ambient conditions via a highly controlled morphological regulation system that uses biological molecules.
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