ArticleApplied and environmental microbiology2011
Global regulation of the response to sulfur availability in the cheese-related bacterium Brevibacterium aurantiacum.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- Sulfur source-driven global remodeling of gene expression in the fuel-biodesulfurizingApplied and environmental microbiology · 2026Article
- Iron limitation promotes metabolic cross-feeding between cheese ripening bacteria.The ISME journal · 2026Article
- Recombinant Expression of L-methioninase fromProtein and peptide letters · 2025Article
- Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizingApplied and environmental microbiology · 2023Article
- Draft genome sequence of a new carotenoid-producing strain3 Biotech · 2022Article
- Article
- Diversity and specificity of the bacterial community in Chinese horse milk cheese.MicrobiologyOpen · 2020Article
- Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.mSystems · 2019Article
- Transcription Profiling Reveals Cooperative Metabolic Interactions in a Microbial Cheese-Ripening Community Composed ofFrontiers in microbiology · 2019Article
- Geotrichum candidum gene expression and metabolite accumulation inside the cells reflect the strain oxidative stress sensitivity and ability to produce flavour compounds.FEMS yeast research · 2019Article
- Isolation and identification of the microbiota of Danish farmhouse and industrially produced surface-ripened cheeses.Microbial ecology · 2013Article
- New insights into sulfur metabolism in yeasts as revealed by studies of Yarrowia lipolytica.Applied and environmental microbiology · 2013Article
- Three-stage assembly of the cysteine synthase complex from Escherichia coli.The Journal of biological chemistry · 2012Article
- Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we combined metabolic reconstruction, growth assays, and metabolome and transcriptome analyses to obtain a global view of the sulfur metabolic network and of the response to sulfur availability in Brevibacterium aurantiacum. In agreement with the growth of B. aurantiacum in the presence of sulfate and cystine, the metabolic reconstruction showed the presence of a sulfate assimilation pathway, thiolation pathways that produce cysteine (cysE and cysK) or homocysteine (metX and metY) from sulfide, at least one gene of the transsulfuration pathway (aecD), and genes encoding three MetE-type methionine synthases. We also compared the expression profiles of B. aurantiacum ATCC 9175 during sulfur starvation or in the presence of sulfate. Under sulfur starvation, 690 genes, including 21 genes involved in sulfur metabolism and 29 genes encoding amino acids and peptide transporters, were differentially expressed. We also investigated changes in pools of sulfur-containing metabolites and in expression profiles after growth in the presence of sulfate, cystine, or methionine plus cystine. The expression of genes involved in sulfate assimilation and cysteine synthesis was repressed in the presence of cystine, whereas the expression of metX, metY, metE1, metE2, and BL613, encoding a probable cystathionine-γ-synthase, decreased in the presence of methionine. We identified three ABC transporters: two operons encoding transporters were transcribed more strongly during cysteine limitation, and one was transcribed more strongly during methionine depletion. Finally, the expression of genes encoding a methionine γ-lyase (BL929) and a methionine transporter (metPS) was induced in the presence of methionine in conjunction with a significant increase in volatile sulfur compound production.
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