ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
PKA and PKC are required for long-term but not short-term in vivo operant memory in Aplysia.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Allies or Enemies? The Power of Plant Hormones in Animals: Insights into Their Regulatory Roles.Molecules (Basel, Switzerland) · 2025Review
- Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023Article
- HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.Communications biology · 2021Article
- Postsynaptic effects ofLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Molecular correlates of separate components of training that contribute to long-term memory formation after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Sleep supports inhibitory operant conditioning memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2017Article
- Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Appetitive Olfactory Learning and Long-Term Associative Memory inFrontiers in behavioral neuroscience · 2017Article
- Article
- Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2016Article
- Associative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory.Neurobiology of learning and memory · 2014Article
- Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Behavioral neuroscience: no easy path from genes to cognition.Current biology : CB · 2012Article
- Massed training-induced intermediate-term operant memory in aplysia requires protein synthesis and multiple persistent kinase cascades.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- PKG-mediated MAPK signaling is necessary for long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Critical role of the circadian clock in memory formation: lessons from Aplysia.Frontiers in molecular neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the involvement of PKA and PKC signaling in a negatively reinforced operant learning paradigm in Aplysia, learning that food is inedible (LFI). In vivo injection of PKA or PKC inhibitors blocked long-term LFI memory formation. Moreover, a persistent phase of PKA activity, although not PKC activity, was necessary for long-term memory. Surprisingly, neither PKA nor PKC activity was required for associative short-term LFI memory. Additionally, PKA and PKC were not required for the retrieval of short- or long-term memory (STM and LTM, respectively). These studies have identified key differences between the mechanisms underlying nonassociative sensitization, operant reward learning, and LFI memory in Aplysia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.