ArticleCancer research2011
A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes.
Article in Cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- ROS-Responsive Nanoprobes for Bimodal Imaging-Guided Cancer Targeted Combinatorial Therapy.International journal of nanomedicine · 2024Article
- The Enigma of Mammaglobin: Redefining the Biomarker Paradigm in Breast Carcinoma.International journal of molecular sciences · 2023Review
- Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2021Article
- Circulating tumor cell characterization of lung cancer brain metastases in the cerebrospinal fluid through single-cell transcriptome analysis.Clinical and translational medicine · 2020Article
- Assessment of Metastatic and Reactive Sentinel Lymph Nodes with B7-H3-Targeted Ultrasound Molecular Imaging: A Longitudinal Study in Mouse Models.Molecular imaging and biology · 2020Article
- Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents.Contrast media & molecular imaging · 2019Article
- Prognostic role of plasma mammaglobin A expression in breast carcinoma patients: a meta-analysis.OncoTargets and therapy · 2018Review
- Cell-surface marker discovery for lung cancer.Oncotarget · 2017Article
- Optical tracer size differences allow quantitation of active pumping rate versus Stokes-Einstein diffusion in lymphatic transport.Journal of biomedical optics · 2016Article
- Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis.Journal of breast cancer · 2016Review
- Cell-surface markers for colon adenoma and adenocarcinoma.Oncotarget · 2016Article
- Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia.Molecular imaging and biology · 2016Article
- Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.Nature communications · 2015Article
- Nodal lymph flow quantified with afferent vessel input function allows differentiation between normal and cancer-bearing nodes.Biomedical optics express · 2015Article
- Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.Nature medicine · 2014Article
- Male breast cancer arising in ectopic axillary breast tissue: A diagnostic dilemma.Oncology letters · 2013Article
- Molecular imaging of breast cancer lymph node metastasis.European journal of radiology · 2012Article
- Article
- Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Pathologic axillary lymph node (ALN) status is an important prognostic factor for staging breast cancer. Currently, status is determined by histopathology following surgical excision of sentinel lymph node(s), which is an invasive, time consuming, and costly procedure with potential morbidity to the patient. Here, we describe an imaging platform for noninvasive assessment of ALN status, eliminating the need for surgical examination of patients to rule out nodal involvement. A targeted imaging probe (MamAb-680) was developed by conjugation of a mammaglobin-A-specific monoclonal antibody to a near-infrared fluorescent dye. Using DNA and tissue microarray, mammaglobin-A was validated as a cell-surface target that is expressed in ALN-positive patient samples but is not expressed in normal lymph nodes. In vivo selectivity was determined by i.v. injection of MamAb-680 into mice with mammaglobin-A-positive and -negative mammary fat pad (MFP) tumors; and by peritumoral MFP injection of the targeted imaging probe in mice with spontaneous ALN metastases. Fluorescence imaging showed that probe was only retained in positive tumors and metastases. As few as 1,000 cells that endogenously express mammaglobin-A were detected in ALN, indicating high sensitivity of this method. Translation of this approach offers considerable potential as a noninvasive clinical strategy to stage breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.