ArticleProceedings of the National Academy of Sciences of the United States of America2011
Completely phased genome sequencing through chromosome sorting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Current Progress in Phased Genome Assembly from Long-Read DNA Sequencing Data.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Long-read-based single sperm genome sequencing for chromosome-wide haplotype phasing of both SNPs and SVs.Nucleic acids research · 2023Article
- Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique.Journal of human genetics · 2022Article
- Isolation and sequencing of a single copy of an introgressed chromosome from a complex genome for gene and SNP identification.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Cataloguing experimentally confirmed 80.7 kb-long ACKR1 haplotypes from the 1000 Genomes Project database.BMC bioinformatics · 2021Article
- Determination of complete chromosomal haplotypes by bulk DNA sequencing.Genome biology · 2021Article
- Performing parentage analysis for polysomic inheritances based on allelic phenotypes.G3 (Bethesda, Md.) · 2021Article
- Gamete binning: chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes.Genome biology · 2020Article
- Inference of Chromosome-Length Haplotypes Using Genomic Data of Three or a Few More Single Gametes.Molecular biology and evolution · 2020Article
- Fully Phased Sequence of a Diploid Human Genome DeterminedG3 (Bethesda, Md.) · 2020Article
- De novo assembly of haplotype-resolved genomes with trio binning.Nature biotechnology · 2018Article
- Homologue-specific chromosome sequencing characterizes translocation junctions and permits allelic assignment.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Long range haplotyping of paired-homologous chromosomes by single-chromosome sequencing of a single cell.Scientific reports · 2018Article
- Article
- Dense and accurate whole-chromosome haplotyping of individual genomes.Nature communications · 2017Article
- Human Genome Sequencing at the Population Scale: A Primer on High-Throughput DNA Sequencing and Analysis.American journal of epidemiology · 2017Review
- Recent Advances in Experimental Whole Genome Haplotyping Methods.International journal of molecular sciences · 2017Review
- Hotspot Selective Preference of the Chimeric Sequences Formed in Multiple Displacement Amplification.International journal of molecular sciences · 2017Article
- Chromosome-Range Whole-Genome High-Throughput Experimental Haplotyping by Single-Chromosome Microdissection.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Haplotyping the human leukocyte antigen system from single chromosomes.Scientific reports · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The two haploid genome sequences that a person inherits from the two parents represent the most fundamentally useful type of genetic information for the study of heritable diseases and the development of personalized medicine. Because of the difficulty in obtaining long-range phase information, current sequencing methods are unable to provide this information. Here, we introduce and show feasibility of a scalable approach capable of generating genomic sequences completely phased across the entire chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.