ArticleEnvironmental health perspectives2011
Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 127 citations in OpenAlex.
- Trial
- Individual and Joint Effect of Particulate Matter and Night-Time Temperature on Sperm Quality: A Large Retrospective Cohort Study in China.Environment & health (Washington, D.C.) · 2026Article
- Particulate matter air pollution: effects on the respiratory system.The Journal of clinical investigation · 2025Review
- Ambient air pollution, genetic risk and telomere length in UK biobank.Journal of exposure science & environmental epidemiology · 2024Article
- Effect of air pollution on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Bronchial cell epigenetic aging in a human experimental study of short-term diesel and ozone exposures.Environmental epigenetics · 2024Article
- Hypertension and cellular senescence.Biogerontology · 2023Review
- Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents.Frontiers in public health · 2023Review
- Long- and Short-Term Exposures to PMLife (Basel, Switzerland) · 2021Article
- Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.Pharmacology & therapeutics · 2021Review
- Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community.Scientific reports · 2021Article
- Single-molecule telomere length characterization by optical mapping in nano-channel array: Perspective and review on telomere length measurement.Environmental toxicology and pharmacology · 2021Review
- The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.Environmental health : a global access science source · 2020Article
- Long-term ozone exposure is positively associated with telomere length in critically ill patients.Environment international · 2020Observational
- Risk Analysis of Air Pollution and Meteorological Factors Affecting the Incidence of Diabetes in the Elderly Population in Northern China.Journal of diabetes research · 2020Article
- Hazardous air pollutants and telomere length in the Sister Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.Environmental research · 2019Article
- Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure.Scientific reports · 2019Article
- Occupational exposure to particulate matters and telomere length.Environmental science and pollution research international · 2018Article
- Air pollution and telomere length: a systematic review of 12,058 subjects.Cardiovascular diagnosis and therapy · 2018Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundShortened leukocyte telomere length (LTL) is a marker of cardiovascular risk that has been recently associated with long-term exposure to ambient particulate matter (PM). However, LTL is increased during acute inflammation and allows for rapid proliferation of inflammatory cells. Whether short-term exposure to proinflammatory exposures such as PM increases LTL has never been evaluated.
objectivesWe investigated the effects of acute exposure to metal-rich PM on blood LTL, as well as molecular mechanisms contributing to LTL regulation in a group of steel workers with high PM exposure.
methodsWe measured LTL, as well as mRNA expression and promoter DNA methylation of the telomerase catalytic enzyme gene [human telomerase reverse transcriptase (hTERT)] in blood samples obtained from 63 steel workers on the first day of a workweek (baseline) and after 3 days of work (postexposure).
resultsLTL was significantly increased in postexposure (mean ± SD, 1.43 ± 0.51) compared with baseline samples (1.23 ± 0.28, p-value < 0.001). Postexposure LTL was positively associated with PM₁₀ (β = 0.30, p-value = 0.002 for 90th vs. 10th percentile exposure) and PM₁ (β = 0.29, p-value = 0.042) exposure levels in regression models adjusting for multiple covariates. hTERT expression was lower in postexposure samples (1.31 ± 0.75) than at baseline (1.68 ± 0.86, p-value < 0.001), but the decrease in hTERT expression did not show a dose-response relationship with PM. We found no exposure-related differences in the methylation of any of the CpG sites investigated in the hTERT promoter.
conclusionsShort-term exposure to PM caused a rapid increase in blood LTL. The LTL increase did not appear to be mediated by PM-related changes in hTERT expression and methylation.
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