ReviewCurrent opinion in cell biology2011
Transcription and recombination factories: common features?
Review in Current opinion in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination.Frontiers in immunology · 2020Review
- The murine IgH locus contains a distinct DNA sequence motif for the chromatin regulatory factor CTCF.The Journal of biological chemistry · 2019Article
- Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.Cell reports · 2016Article
- Article
- The establishment of B versus T cell identity.Trends in immunology · 2014Review
- Function of YY1 in Long-Distance DNA Interactions.Frontiers in immunology · 2014Review
- Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.The EMBO journal · 2013Article
- Review
- Recovering ensembles of chromatin conformations from contact probabilities.Nucleic acids research · 2013Article
- The role of CTCF in regulating V(D)J recombination.Current opinion in immunology · 2012Review
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations.BMC biophysics · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
There is now substantial evidence that the eukaryotic nucleus consists of highly organized structures. Among such structures are transcription factories that consist of an ensemble of genes recruited by the RNA polymerase machinery. Here we suggest that antigen receptor variable regions are similarly organized. Specifically, we propose that the immunoglobulin heavy chain locus variable gene segments are anchored to the base of rosettes, wrapping around a cavity that contains the recombination machinery. We suggest that the folding of the chromatin fiber into rosettes underpins a crucial mechanism by which antigen receptor diversity is generated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.