Evidence map›Paper›PMID 21168944›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2011

Surrogate markers of cardiovascular disease in CKD: what's under the hood?

Mario F Rubin, Sylvia E Rosas, Julio A Chirinos, Raymond R Townsend

Registry-linked trialAbstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01796418 (Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01796418 naunknown statusnot on this mapstarted 2013, after this paper: background citation

Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy (BESTinDN Study)

TypeinterventionalSponsorSeoul National University HospitalRan2013Enrolled102ConditionsDiabetic NephropathyArmsBeraprost sodium
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Cardiovascular risk factors in children on dialysis: an update.Pediatric nephrology (Berlin, Germany) · 2020
    Review
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Blood pressure measurement: clinic, home, ambulatory, and beyond.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mario F RubinMassachussetts General Hospital, Boston, MA, USA. mfrubin@partners.org
Sylvia E Rosas
Julio A Chirinos
Raymond R Townsend

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Pulse wave velocity in chronic kidney diseasesR01DK067390 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TOWNSEND, RAYMOND R · 2005 to 2013
$4.3M
Inflammatory response to sleep apnea in obese subjectsR01HL080076 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2006 to 2010
$3.5M
Carotid Intima-Media Thickness in Chronic Kidney Disease: a CRIC ancillary studyR01DK080033 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ROSAS, SYLVIA E · 2008 to 2012
$1.7M
NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1-RR024134NHLBI NIH HHS R01 HL080076NHLBI NIH HHS R01-HL080076NIDDK NIH HHS DK-067390NIDDK NIH HHS R01 DK067390NIDDK NIH HHS R01 DK080033NIDDK NIH HHS R01DK080033
6 · The paper itself

Abstract

Although clinical cardiovascular outcomes, such as heart attack, stroke, and sudden cardiac death, have a dramatic onset, they result from prolonged exposure to an ever-growing array of risk factors. Several noninvasive procedures are available to assess the cumulative effect of these exposures with the goal of more precisely estimating a person's cardiovascular risk. These include ankle-brachial index, which provides an estimation of obstruction in major-vessel lumen caliber; carotid ultrasound, which evaluates carotid intima-media thickness and plaque, visibly quantifying atherosclerotic burden; aortic pulse wave velocity, which provides a measure of large-artery stiffness; and echocardiography, which measures left ventricular mass, providing a measure of subclinical hypertensive heart disease. In this narrative review, we discuss the role of each of these measures, with a particular emphasis on patients with chronic kidney disease.

Indexed as

VasodilationCardiovascular DiseasesCarotid Artery, CommonEchocardiographyHeart VentriclesHumansKidney Failure, ChronicMagnetic Resonance Imaging, CineReproducibility of ResultsUltrasonography, Doppler, Color

Identifiers

PMID21168944
PMCPMC12684143

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.