Evidence map›Paper›PMID 21168504›Full record

ReviewSeminars in cancer biology2011

Metastasis suppressors and the tumor microenvironment.

Leah M Cook, Douglas R Hurst, Danny R Welch

Abstract readReview
In one paragraph

Review in Seminars in cancer biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. A survey of metastasis suppressors in Metazoa.Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cancer Metastases: So Close and So Far.Journal of the National Cancer Institute · 2015
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Leah M CookDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Douglas R Hurst
Danny R Welch
University of Alabama at Birmingham · US

Funding

Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
MOLECULAR REGULATION OF BREAST CANCER METASTASISR01CA087728 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELCH, DANNY R. · 2000 to 2008
$2.7M
KISS1: Defining Mechanisms for Antimetastatic TherapyR01CA134981 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WELCH, DANNY R. · 2009 to 2014
$1.5M
METASTASIS SUPPRESSOR GENES IN HUMAN CUTANEOUS MELANOMAR01CA062168 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WELCH, DANNY R · 1994 to 1999
–
NCI NIH HHS CA062168NCI NIH HHS CA087728NCI NIH HHS CA134981NCI NIH HHS R01 CA062168NCI NIH HHS R01 CA087728NCI NIH HHS R01 CA134981NCI NIH HHS R25 CA047888NCI NIH HHS T32-R25CA047888
6 · The paper itself

Abstract

The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

Indexed as

Tumor MicroenvironmentAnimalsCell Adhesion MoleculesExtracellular MatrixGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisReceptors, Cell SurfaceSignal TransductionTumor Suppressor ProteinsCell Adhesion MoleculesReceptors, Cell SurfaceTumor Suppressor Proteins

Identifiers

PMID21168504
PMCPMC3053584
OpenAlexW2019579079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.