ReviewMethods (San Diego, Calif.)2011
Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise.
Review in Methods (San Diego, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- HIV-Tocky system to visualize proviral expression dynamics.Communications biology · 2024Article
- CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells.Journal of virology · 2023Article
- TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.Communications biology · 2023Article
- HIV-1 Tat endocytosis and retention in endolysosomes affects HIV-1 Tat-induced LTR transactivation in astrocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- A Stronger Transcription Regulatory Circuit of HIV-1C Drives the Rapid Establishment of Latency with Implications for the Direct Involvement of Tat.Journal of virology · 2020Article
- HIV-1 Proviral Transcription and Latency in the New Era.Viruses · 2020Review
- Stochastic modeling of human papillomavirusearly promoter gene regulation.Journal of theoretical biology · 2020Article
- Transcriptional Circuit Fragility Influences HIV Proviral Fate.Cell reports · 2019Article
- Probabilistic control of HIV latency and transactivation by the Tat gene circuit.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Compounds producing an effective combinatorial regimen for disruption of HIV-1 latency.EMBO molecular medicine · 2018Article
- A strategy for effective latent HIV reactivation using subtherapeutic drug doses.Scientific reports · 2017Article
- Distinct promoter activation mechanisms modulate noise-driven HIV gene expression.Scientific reports · 2015Article
- A hardwired HIV latency program.Cell · 2015Article
- HIV latency and integration site placement in five cell-based models.Retrovirology · 2013Article
- Building a super elongation complex for HIV.eLife · 2013Article
- Fluctuations in Tat copy number when it counts the most: a possible mechanism to battle the HIV latency.Theoretical biology & medical modelling · 2013Article
- Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes.Lab on a chip · 2012Article
- Dynamics of protein noise can distinguish between alternate sources of gene-expression variability.Molecular systems biology · 2012Article
- The control of HIV transcription: keeping RNA polymerase II on track.Cell host & microbe · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Upon infection of a CD4(+) T cell, HIV-1 appears to 'choose' between two alternate fates: active replication or a long-lived dormant state termed proviral latency. A transcriptional positive-feedback loop generated by the HIV-1 Tat protein appears sufficient to mediate this decision. Here, we describe a coupled wet-lab and computational approach that uses mathematical modeling and live-cell time-lapse microscopy to map the architecture of the HIV-1 Tat transcriptional regulatory circuit and generate predictive models of HIV-1 latency. This approach provided the first characterization of a 'decision-making' circuit that lacks bistability and instead exploits stochastic fluctuations in cellular molecules (i.e. noise) to generate a decision between an on or off transcriptional state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.