ArticleRespiratory physiology & neurobiology2011
Reduced respiratory neural activity elicits phrenic motor facilitation.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Intermittent phrenic afferent activation induces phrenic motor plasticity.Journal of neurophysiology · 2026Article
- Feasibility of transcranial magnetic stimulation adjuvant therapy for chronic respiratory diseases: a narrative review.Frontiers in rehabilitation sciences · 2026Review
- Perineuronal Net Changes Reveal a Distinct Right and Left Spinal Phrenic Circuit.Journal of neurotrauma · 2025Article
- Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons.Journal of neurophysiology · 2024Article
- Spinal TNF-α receptor 1 is differentially required for phrenic long-term facilitation (pLTF) over the course of motor neuron death in adult rats.Frontiers in physiology · 2024Article
- Novel role for non-invasive neuromodulation techniques in central respiratory dysfunction.Frontiers in neuroscience · 2023Review
- Inactivity and CaScientific reports · 2022Article
- Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections.Experimental neurology · 2022Article
- Phrenic afferent activation modulates cardiorespiratory output in the adult rat.Journal of neurophysiology · 2021Article
- Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.Journal of neurophysiology · 2021Article
- Retinoic acid receptor alpha activation is necessary and sufficient for plasticity induced by recurrent central apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Competing mechanisms of plasticity impair compensatory responses to repetitive apnoea.The Journal of physiology · 2019Article
- Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.Journal of neurophysiology · 2017Article
- High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.Journal of neurophysiology · 2017Article
- Coupling multielectrode array recordings with silver labeling of recording sites to study cervical spinal network connectivity.Journal of neurophysiology · 2017Article
- Reduced respiratory neural activity elicits a long-lasting decrease in the COExperimental neurology · 2017Article
- Plasticity in respiratory motor neurons in response to reduced synaptic inputs: A form of homeostatic plasticity in respiratory control?Experimental neurology · 2017Review
- Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea.Journal of neurophysiology · 2015Article
- Intermittent reductions in respiratory neural activity elicit spinal TNF-α-independent, atypical PKC-dependent inactivity-induced phrenic motor facilitation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We hypothesized that reduced respiratory neural activity elicits compensatory mechanisms of plasticity that enhance respiratory motor output. In urethane-anesthetized and ventilated rats, we reversibly reduced respiratory neural activity for 25-30 min using: hypocapnia (end tidal CO(2)=30 mmHg), isoflurane (~1%) or high frequency ventilation (HFV; ~100 breaths/min). In all cases, increased phrenic burst amplitude was observed following restoration of respiratory neural activity (hypocapnia: 92±22%; isoflurane: 65±22%; HFV: 54±13% baseline), which was significantly greater than time controls receiving the same surgery, but no interruptions in respiratory neural activity (3±5% baseline, p<0.05). Hypocapnia also elicited transient increases in respiratory burst frequency (9±2 versus 1±1bursts/min, p<0.05). Our results suggest that reduced respiratory neural activity elicits a unique form of plasticity in respiratory motor control which we refer to as inactivity-induced phrenic motor facilitation (iPMF). iPMF may prevent catastrophic decreases in respiratory motor output during ventilatory control disorders associated with abnormal respiratory activity.
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Registered trials
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