ArticleNeuropsychologia2011
The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces.
Article in Neuropsychologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis.Molecular psychiatry · 2013Pooled it
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.Brain sciences · 2024Article
- Article
- Increased ASL-CBF in the right amygdala predicts the first onset of depression in healthy young first-degree relatives of patients with major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Article
- Heightened amygdala responsiveness in s-carriers of 5-HTTLPR genetic polymorphism reflects enhanced cortical rather than subcortical inputs: An MEG study.Human brain mapping · 2017Article
- Individual Differences in the Speed of Facial Emotion Recognition Show Little Specificity but Are Strongly Related with General Mental Speed: Psychometric, Neural and Genetic Evidence.Frontiers in behavioral neuroscience · 2017Article
- Emotion moderates the association between HTR2A (rs6313) genotype and antisaccade latency.Experimental brain research · 2016Article
- Early event-related potentials to emotional faces differ for adults with autism spectrum disorder and by serotonin transporter genotype.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
- Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli.Journal of affective disorders · 2016Article
- Recent advances in the genetics of emotion regulation: a review.Current opinion in psychology · 2015Article
- Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.Emotion (Washington, D.C.) · 2013Article
- A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology.Molecular psychiatry · 2013Review
- The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.Neuroscience bulletin · 2013Article
- Neurobiological markers of familial risk for depression.Current topics in behavioral neurosciences · 2013Review
- Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- 5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents.NeuroImage · 2012Article
- Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.The International journal of eating disorders · 2012Article
- Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells.Translational psychiatry · 2012Article
Corrections and comments
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5 authors.
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Abstract
Previous research has found that a common polymorphism in the serotonin transporter gene (5-HTTLPR) is an important mediator of individual differences in brain responses associated with emotional behaviour. In particular, relative to individuals homozygous for the l-allele, carriers of the s-allele display heightened amygdala activation to emotional compared to non-emotional stimuli. However, there is some debate as to whether this difference is driven by increased activation to emotional stimuli, resting baseline differences between the groups, or decreased activation to neutral stimuli. We performed functional imaging during an implicit facial expression processing task in which participants viewed angry, sad and neutral faces. In addition to neutral faces, we included two further baseline conditions, houses and fixation. We found increased amygdala activation in s-allele carriers relative to l-homozygotes in response to angry faces compared to neutral faces, houses and fixation. When comparing neutral faces to houses or fixation, we found no significant difference in amygdala response between the two groups. In addition, there was no significant difference between the groups in response to fixation when compared with a houses baseline. Overall, these results suggest that the increased amygdala response observed in s-allele carriers to emotional faces is primarily driven by an increased response to emotional faces rather than a decreased response to neutral faces or an increased resting baseline. The results are discussed in relation to the tonic and phasic hypotheses of 5-HTTLPR-mediated modulation of amygdala activity.
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