ArticleMathematical biosciences2011
A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system.
Article in Mathematical biosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells.Acta pharmacologica Sinica · 2026Article
- Bicarbonate-integrated transarterial chemoembolization (TACE) in real-world hepatocellular carcinoma.Signal transduction and targeted therapy · 2025Article
- Modulating Nonlinear Acoustic Response of Phospholipid-Coated Microbubbles with pH for Ultrasound Imaging.ACS sensors · 2024Article
- Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment.Asian journal of pharmaceutical sciences · 2023Article
- Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function.Oncogene · 2022Article
- Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions.Biomolecules · 2020Article
- The control of acidity in tumor cells: a biophysical model.Scientific reports · 2020Article
- Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCOCancers · 2020Article
- Quantification of lactate from various metabolic pathways and quantification issues of lactate isotopologues and isotopmers.Scientific reports · 2017Article
- NaHCOOncology letters · 2016Article
- Article
- Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect.Cell proliferation · 2015Article
- Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI.Magnetic resonance in medicine · 2014Article
- A general reaction-diffusion model of acidity in cancer invasion.Journal of mathematical biology · 2014Article
- Multiscale imaging and computational modeling of blood flow in the tumor vasculature.Annals of biomedical engineering · 2012Review
- Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study.British journal of cancer · 2012Article
- Measuring in vivo tumor pHe with CEST-FISP MRI.Magnetic resonance in medicine · 2012Article
- Drug resistance and cellular adaptation to tumor acidic pH microenvironment.Molecular pharmaceutics · 2011Review
- Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation.Signal transduction and targeted therapyArticle
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Malignant tumours are characterised by a low, acidic extracellular pH (pHe) which facilitates invasion and metastasis. Previous research has proposed the potential benefits of manipulating systemic pHe, and recent experiments have highlighted the potential for buffer therapy to raise tumour pHe, prevent metastases, and prolong survival in laboratory mice. To examine the physiological regulation of tumour buffering and investigate how perturbations of the buffering system (via metabolic/respiratory disorders or changes in parameters) can alter tumour and blood pHe, we develop a simple compartmentalised ordinary differential equation model of pHe regulation by the HCO3-/CO2 buffering system. An approximate analytical solution is constructed and used to carry out a sensitivity analysis, where we identify key parameters that regulate tumour pHe in both humans and mice. From this analysis, we suggest promising alternative and combination therapies, and identify specific patient groups which may show an enhanced response to buffer therapy. In addition, numerical simulations are performed, validating the model against well-known metabolic/respiratory disorders and predicting how these disorders could change tumour pHe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.