Trial reportMicrocirculation (New York, N.Y. : 1994)2011
Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment.
Trial report in Microcirculation (New York, N.Y. : 1994), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00666029. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implications for Treatment of the Metabolic Syndrome
Open the trial in the graphWho cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Dysregulated Neurovascular Control Underlies Declining Microvascular Functionality in People With Non-alcoholic Fatty Liver Disease (NAFLD) at Risk of Liver Fibrosis.Frontiers in physiology · 2020Article
- Insulin-resistant subjects have normal angiogenic response to aerobic exercise training in skeletal muscle, but not in adipose tissue.Physiological reports · 2015Article
- Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Microvascular reactivity in women with gestational diabetes mellitus studied during pregnancy.Diabetology & metabolic syndrome · 2015Article
- Microvascular dysfunction: an emerging pathway in the pathogenesis of obesity-related insulin resistance.Reviews in endocrine & metabolic disorders · 2013Review
- Peripheral vascular response to inspiratory breath hold in paediatric homozygous sickle cell disease.Experimental physiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
methodsFunctional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
resultsInsulin-induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = -0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r² = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
conclusionsInsulin sensitivity and age are independently associated with an insulin-induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.