ArticleMolecular microbiology2011
Regulation of the phototrophic iron oxidation (pio) genes in Rhodopseudomonas palustris TIE-1 is mediated by the global regulator, FixK.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- The AadR-FixK hierarchy coordinates iron-responsive metabolism via Fur-family regulators inbioRxiv : the preprint server for biology · 2026Article
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- Overexpression of RuBisCO form I and II genes inApplied and environmental microbiology · 2024Article
- The phototrophic purple non-sulfur bacteria Rhodomicrobium spp. are novel chassis for bioplastic production.Microbial biotechnology · 2024Article
- Multidimensional optimization for accelerating light-powered biocatalysis in Rhodopseudomonas palustris.Biotechnology for biofuels and bioproducts · 2023Article
- Redox signaling-driven modulation of microbial biosynthesis and biocatalysis.Nature communications · 2023Article
- PioABC-Dependent Fe(II) Oxidation during Photoheterotrophic Growth on an Oxidized Carbon Substrate Increases Growth Yield.Applied and environmental microbiology · 2022Article
- Electroactive biofilms: how microbial electron transfer enables bioelectrochemical applications.Journal of industrial microbiology & biotechnology · 2022Review
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- A comparative metabologenomic approach reveals mechanistic insights intoProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic Redundancy in Iron and Manganese Transport in the Metabolically Versatile Bacterium Rhodopseudomonas palustris TIE-1.Applied and environmental microbiology · 2020Article
- Article
- Towards sustainable bioplastic production using the photoautotrophic bacterium Rhodopseudomonas palustris TIE-1.Journal of industrial microbiology & biotechnology · 2019Article
- Proteome Response of a Metabolically Flexible Anoxygenic Phototroph to Fe(II) Oxidation.Applied and environmental microbiology · 2018Article
- A physiological perspective on the origin and evolution of photosynthesis.FEMS microbiology reviews · 2018Review
- Development of a Genetic System forFrontiers in microbiology · 2018Article
- Nutrient Acquisition and the Metabolic Potential of Photoferrotrophic Chlorobi.Frontiers in microbiology · 2017Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
The pioABC operon is required for phototrophic iron oxidative (photoferrotrophic) growth by the α-proteobacterium Rhodopseudomonas palustris TIE-1. Expression analysis of this operon showed that it was transcribed and translated during anaerobic growth, upregulation being observed only under photoferrotrophic conditions. Very low levels of transcription were observed during aerobic growth, suggesting expression was induced by anoxia. The presence of two canonical FixK boxes upstream of the identified pioABC transcription start site implicated FixK as a likely regulator. To test this possibility, a ΔfixK mutant of R. palustris TIE-1 was assessed for pioABC expression. pioABC expression decreased dramatically in ΔfixK versus WT during photoferrotrophic growth, implying that FixK positively regulates its expression; coincidently, the onset of iron oxidation was prolonged in this mutant. In contrast, pioABC expression increased in ΔfixK under all non-photoferrotrophic conditions tested, suggesting the presence of additional levels of regulation. Purified FixK directly bound only the proximal FixK box in gel mobility-shift assays. Mutant expression analysis revealed that FixK regulates anaerobic phototrophic expression of other target genes with FixK binding sites in their promoters. This study shows that FixK regulates key iron metabolism genes in an α-proteobacterium, pointing to a departure from the canonical Fur/Irr mode of regulation.
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