ArticleEvolution; international journal of organic evolution2011
A case-by-case evolutionary analysis of four imprinted retrogenes.
Article in Evolution; international journal of organic evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Transcriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus.Nucleic acids research · 2026Article
- NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.BMC cancer · 2022Article
- Article
- Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing.Nucleic acids research · 2020Article
- Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana.Molecular biology and evolution · 2019Article
- NAP1L1 is a prognostic biomarker and contribute to doxorubicin chemotherapy resistance in human hepatocellular carcinoma.Cancer cell international · 2019Article
- Genome-wide methylation analysis of retrocopy-associated CpG islands and their genomic environment.Epigenetics · 2016Article
- Epigenetic changes in the developing brain: Effects on behavior.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications.Heredity · 2014Review
- Different yet similar: evolution of imprinting in flowering plants and mammals.F1000prime reports · 2014Review
- RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis.Development (Cambridge, England) · 2013Article
- Importance of the matriline for genomic imprinting, brain development and behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Neocortical development as an evolutionary platform for intragenomic conflict.Frontiers in neuroanatomy · 2013Article
- Article
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8 authors.
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Abstract
Retroposition is a widespread phenomenon resulting in the generation of new genes that are initially related to a parent gene via very high coding sequence similarity. We examine the evolutionary fate of four retrogenes generated by such an event; mouse Inpp5f_v2, Mcts2, Nap1l5, and U2af1-rs1. These genes are all subject to the epigenetic phenomenon of parental imprinting. We first provide new data on the age of these retrogene insertions. Using codon-based models of sequence evolution, we show these retrogenes have diverse evolutionary trajectories, including divergence from the parent coding sequence under positive selection pressure, purifying selection pressure maintaining parent-retrogene similarity, and neutral evolution. Examination of the expression pattern of retrogenes shows an atypical, broad pattern across multiple tissues. Protein 3D structure modeling reveals that a positively selected residue in U2af1-rs1, not shared by its parent, may influence protein conformation. Our case-by-case analysis of the evolution of four imprinted retrogenes reveals that this interesting class of imprinted genes, while similar in regulation and sequence characteristics, follow very varied evolutionary paths.
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