ArticleMicrobial drug resistance (Larchmont, N.Y.)2011
Identification of a novel keyhole phenotype in double-disk diffusion assays of clindamycin-resistant erythromycin-sensitive strains of Streptococcus agalactiae.
Article in Microbial drug resistance (Larchmont, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.Journal of food science and technology · 2023Article
- Human enterococcal isolates as reservoirs for macrolide-lincosamide-streptogramin and other resistance genes.The Journal of antibiotics · 2022Article
- Heterogeneity of macrolide-lincosamide-streptogramin phenotype & conjugal transfer ofThe Indian journal of medical research · 2019Article
- Prevalence of Multidrug-ResistantInfectious diseases · 2019Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
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Abstract
Our objective was to characterize 46 unique, erythromycin-sensitive, and clindamycin-resistant Streptococcus agalactiae strains from S. Korea that displayed a novel phenotype in double-disk diffusion assay. We used polymerase chain reaction to determine presence of erythromycin and clindamycin resistance genes, disc diffusion assays to determine resistance phenotype, and microbroth dilution to determine minimal inhibitory concentration. We detected a novel phenotype in the double-disk diffusion assay for inducible resistance among 46 S. agalactiae strains that were both erythromycin sensitive and clindamycin resistant. Thirty-two strains with the novel phenotype tested positive for erm(B) by DNA-DNA hybridization; sequencing of the erm(B) gene revealed mutations in the ribosomal binding site region in the erm(B) open reading frame, which is consistent with a lack of erythromycin resistance phenotype. Although identified from patients at multiple hospitals, genotyping suggested that the strains are closely related. The new phenotype shows increased sensitivity to clindamycin in the presence of erythromycin.
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