ArticleThe Journal of comparative neurology2011
Brain expression and song regulation of the cholecystokinin gene in the zebra finch (Taeniopygia guttata).
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- The role of dorsal raphe nucleus neuropeptides in reward and aversion.Frontiers in behavioral neuroscience · 2025Review
- The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning.Annals of the New York Academy of Sciences · 2022Article
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Cholecystokinin induces crowing in chickens.Scientific reports · 2019Article
- Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds.Scientific reports · 2019Article
- The constitutive differential transcriptome of a brain circuit for vocal learning.BMC genomics · 2018Article
- Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles).Scientific reports · 2015Article
- The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.Neuroscience and biobehavioral reviews · 2015Review
- An optimized protocol for high-throughput in situ hybridization of zebra finch brain.Cold Spring Harbor protocols · 2014Article
- Genomics analysis of potassium channel genes in songbirds reveals molecular specializations of brain circuits for the maintenance and production of learned vocalizations.BMC genomics · 2013Article
- Decreased expression of the satiety signal receptor CCKAR is responsible for increased growth and body weight during the domestication of chickens.American journal of physiology. Endocrinology and metabolism · 2013Article
- Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior.Molecular neurobiology · 2011Review
- Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Accelerated evolution of PAK3- and PIM1-like kinase gene families in the zebra finch, Taeniopygia guttata.Molecular biology and evolution · 2010Article
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2 authors at 1 institution in 1 country.
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Abstract
The gene encoding cholecystokinin (Cck) is abundantly expressed in the mammalian brain and has been associated with such functions as feeding termination and satiety, locomotion and self-stimulation, the modulation of anxiety-like behaviors, and learning and memory. Here we describe the brain expression and song regulation of Cck in the brain of the adult male zebra finch (Taeniopygia guttata), a songbird species. Using in situ hybridization we demonstrate that Cck is highly expressed in several discrete brain regions, most prominently the caudalmost portion of the hippocampal formation, the caudodorsal nidopallial shelf and the caudomedial nidopallium (NCM), the core or shell regions of dorsal thalamic nuclei, dopaminergic cell groups in the mesencephalon and pons, the principal nucleus of the trigeminal nerve, and the dorsal raphe. Cck was largely absent in song control system, a group of nuclei required for vocal learning and song production in songbirds, although sparse labeling was detected throughout the striatum, including song nucleus area X. We also show that levels of Cck mRNA and the number of labeled cells increase in the NCM of males and females following auditory stimulation with conspecific song. Double labeling further reveals that the majority of Cck cells, excluding those in the reticular nucleus of the thalamus, are non-GABAergic. Together, these data provide the first comprehensive characterization of Cck expression in a songbird, and suggest a possible involvement of Cck regulation in important aspects of birdsong biology, such as perceptual processing, auditory memorization, and/or vocal-motor control of song production.
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