ArticleJournal of neurovirology2011
Neurotrophins modulate the expression of chemokine receptors in the brain.
Article in Journal of neurovirology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Relationship between CXCR4 and GNG4 in the Brain and Chronic Stress-Induced Atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Differential effects of fentanyl compared to morphine on neuroinflammatory signaling in the brain in EcoHIV-infected mice.Journal of neurovirology · 2025Article
- Multi-chemokine receptor antagonist RAP-103 inhibits opioid-derived respiratory depression, reduces opioid reinforcement and physical dependence, and normalizes opioid-induced dysregulation of mesolimbic chemokine receptors in rats.Drug and alcohol dependence · 2022Article
- Chemokine CCR5 and cocaine interactions in the brain: Cocaine enhances mesolimbic CCR5 mRNA levels and produces place preference and locomotor activation that are reduced by a CCR5 antagonist.Brain, behavior, and immunity · 2020Article
- The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5.Journal of neurochemistry · 2018Article
- Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia.Journal of pain research · 2017Article
- Urinary Levels of IL-1Mediators of inflammation · 2017Observational
- Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain.Frontiers in neuroanatomy · 2017Article
- Pharmacological induction of CCL5 in vivo prevents gp120-mediated neuronal injury.Neuropharmacology · 2015Article
- Systematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders.Frontiers in cellular neuroscience · 2015Review
- CCL5 and cytokine expression in the rat brain: differential modulation by chronic morphine and morphine withdrawal.Brain, behavior, and immunity · 2013Article
- When human immunodeficiency virus meets chemokines and microglia: neuroprotection or neurodegeneration?Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport.Neurotoxicity research · 2012Review
- Beyond the Brain: The Role of Brain-Derived Neurotrophic Factor in Viroimmune Responses to Antiretroviral Therapy among People Living with HIV with and without Alcohol Use.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In the central nervous system, chemokines are primarily mediators of inflammatory processes. Their receptors, in particular, CXCR4 and CCR5, serve as co-factors along with CD4 that permit Human immunodeficiency virus-1 (HIV) infection. Moreover, experimental evidence has shown that CXCR4 and CCR5 mediate the neurotoxic effects of the HIV envelope protein gp120, suggesting that these receptors could also promote the neuropathogenesis observed in HIV-positive individuals. Therefore, a better understanding of the molecular mechanisms governing the expression of chemokine receptors in the brain may lead to improved therapies that reduce HIV neurotoxicity. This study presents evidence that the expression of chemokine receptors in the brain is modulated by two neurotrophins in an area-specific manner. This new evidence suggests that the neurotrophins may be an adjunct therapy to reduce HIV-mediated neuronal injury evoked by chemokine receptor activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.