ReviewEuropean journal of pediatrics2011
Clinical practice: the management of hyperammonemia.
Review in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 125 citations in OpenAlex.
- Diagnostics of Inherited Metabolic Diseases in Newborns with the Hyperammonemia Syndrome at the Onset of Disease (Pilot Study).Sovremennye tekhnologii v meditsine · 2021Trial
- Relationship between the incidence of non-hepatic hyperammonemia and the prognosis of patients in the intensive care unit.World journal of gastroenterology · 2020Trial
- Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial.Pediatric research · 2020Trial
- Hyperammonaemic encephalopathy following bariatric surgery: detailed biochemical phenotyping and pathophysiology informed treatment.European journal of clinical nutrition · 2026Article
- Article
- Longitudinal urine metabolomics predicts high-grade brain injury in very preterm infants.Pediatric research · 2026Article
- Endoscopic reversal of Roux-en-Y gastric bypass using lumen-apposing metal stent for the treatment of excessive weight loss and hyperammonemic encephalopathy.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2026Article
- The Usefulness of Basic Laboratory Analyses in Diagnostics of Inherited Metabolic Diseases in Children.Diagnostics (Basel, Switzerland) · 2025Review
- Practical Considerations for the Diagnosis and Management of Isovaleryl-CoA-Dehydrogenase Deficiency (Isovaleric Acidemia): Systematic Search and Review and Expert Opinions.International journal of neonatal screening · 2025Review
- Hyperammonaemia in Dogs Presenting with Acute Epileptic Seizures-More than Portosystemic Shunts.Animals : an open access journal from MDPI · 2025Article
- Asparaginase-associated hyperammonemia.Haematologica · 2025Review
- Valproate-induced hyperammonemic encephalopathy: the role of clinical pharmacists in medication safety-a case report.Journal of medical case reports · 2025Article
- Novel roles of ammonia in physiology and cancer.Journal of molecular cell biology · 2025Review
- Advances in Genetic Testing of Neurologically Abnormal Neonates in the Neonatal Intensive Care Unit.Clinics in perinatology · 2025Review
- Comparative efficacy of levofloxacin, azithromycin, and doxycycline prophylaxis and treatment in an experimentalAntimicrobial agents and chemotherapy · 2025Article
- Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024.Frontiers in pharmacology · 2025Article
- Characterization and treatment monitoring of ureagenesis disorders using stable isotopes.npj metabolic health and disease · 2025Article
- Role of carglumic acid in the long-term management of propionic and methylmalonic acidurias.Orphanet journal of rare diseases · 2024Review
- Prognostic value of serum ammonia in critical patients with non-hepatic disease: A prospective, observational, multicenter study.Journal of translational internal medicine · 2023Article
- Genetic background and clinical characteristics of infantile hyperammonemia.Translational pediatrics · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperammonemia is a life-threatening condition which can affect patients at any age. Elevations of ammonia in plasma indicate its increased production and/or decreased detoxification. The hepatic urea cycle is the main pathway to detoxify ammonia; it can be defective due to an inherited enzyme deficiency or secondary to accumulated toxic metabolites or substrate depletion. Clinical signs and symptoms in hyperammonemia are unspecific but they are mostly neurological. Thus, in any unexplained change in consciousness or in any unexplained encephalopathy, hyperammonemia must be excluded as fast as possible. Any delay in recognition and start of treatment of hyperammonemia may have deleterious consequences for the patient. Treatment largely depends on the underlying cause but is, at least in pediatric patients, mainly aimed at establishing anabolism to avoid endogenous protein breakdown and amino acid imbalances. In addition, pharmacological treatment options exist to improve urea cycle function or to remove nitrogen, but their use depend on the underlying disorder. To improve the prognosis of acute hyperammonemia, an increased awareness of this condition is probably more needed than anything else. Likewise, the immediate start of appropriate therapy is of utmost importance. This review focuses on a better understanding of factors leading to ammonia elevations and on practical aspects related to diagnosis and treatment in order to improve clinical management of hyperammonemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.