ReviewJournal of neural transmission (Vienna, Austria : 1996)2011
AED discontinuation may be dangerous for seizure-free patients.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 33 citations in OpenAlex.
- A Narrative Review on the Effect of Valproic Acid on the Placenta.Birth defects research · 2025Review
- A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs.Epilepsia · 2021Article
- [Risk factors for 5-year recurrence of spontaneous symptomatic epileptic seizures in infants and young children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Withdrawal of antiepileptic drugs in glioma patients after long-term seizure freedom: design of a prospective observational study.BMC neurology · 2014Observational
- Juvenile myoclonic epilepsy: when will it end.Epilepsy currents · 2013Article
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1 author at 1 institution in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Despite its benefits, stopping antiepileptic drugs (AEDs) in seizure-free patients is associated with several risks. AED discontinuation doubles the risk of seizure recurrence for up to 2 years compared with continued treatment. On average, one in three patients has a seizure recurrence, though the range can go up to 66% (34%, range 12-66%, 95% CI: 27-43). Furthermore, the outcome of treating a seizure recurrence in patients who have been seizure-free for years is surprisingly poor in some patients. Although the long-term prognosis is not worsened by drug discontinuation, one in five patients does not re-enter remission and for some patients, it may take several years to become seizure-free again. The risk of seizure recurrence is particularly high for those with juvenile myoclonic epilepsy and symptomatic focal epilepsy, the most frequent epilepsies in adults. Seizure-recurrence may have devastating, medical, psychological and social consequences for the individual, for example injury, loss of self-esteem, unemployment and losing a driver's license. Discontinuation should be avoided in patients with a high risk of seizure recurrence. Given these risks, patients will ultimately have to decide themselves whether they wish to discontinue drug treatment after full informed consent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.