Evidence map›Paper›PMID 21165341›Full record

ReviewThe Yale journal of biology and medicine2010

Pathogenic bacteria as vaccine vectors: teaching old bugs new tricks.

Heather A Carleton

Abstract readReview
In one paragraph

Review in The Yale journal of biology and medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Nanomedicine: New Frontiers in Fighting Microbial Infections.Nanomaterials (Basel, Switzerland) · 2023
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. A safe bacterial microsyringe for in vivo antigen delivery and immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Heather A CarletonSection of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA. heather.carleton@yale.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As our scientific knowledge of bacteria grows, so does our ability to manipulate these bacteria to protect rather than infect mammalian hosts from a diverse group of diseases. The old axiom that the best way to protect from a disease is to get infected in the first place is not feasible in the face of the diverse group of pathogens that infect humans. Therefore, reprogramming bacteria to protect against diverse bacterial, viral, and parasitic diseases as well as cancer is a new reality in the field of vaccines.

Indexed as

Adaptive ImmunityAnimalsBacteriaHumansImmunity, InnateVaccinesVaccinesantigen expressionattenuated bacteriabacterial vaccine vectorsorally administered vaccinesSalmonella vaccinestype III secretion system/vaccinesvaccines/adaptive immunityvaccines/innate immunityvaccine vectors

Identifiers

PMID21165341
PMCPMC3002147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.