ArticleOptics express2010
Spectroscopic optical coherence elastography.
Article in Optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Chirp excitation for natural frequency optical coherence elastography.Biomedical optics express · 2024Article
- Dual-channel air-pulse optical coherence elastography for frequency-response analysis.Biomedical optics express · 2024Article
- Electronic frequency shifting enables long, variable working distance optical coherence tomography.Biomedical optics express · 2023Article
- Review
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Spatial Assessment of Heterogeneous Tissue Natural Frequency Using Micro-Force Optical Coherence Elastography.Frontiers in bioengineering and biotechnology · 2022Article
- In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.Journal of biomechanics · 2021Article
- Biomechanical sensing ofTheranostics · 2021Article
- Single-shot two-dimensional spectroscopic magnetomotive optical coherence elastography with graphics processing unit acceleration.Optics letters · 2020Article
- Characterization of natural frequencies from nanoscale tissue oscillations using dynamic optical coherence elastography.Biomedical optics express · 2020Article
- Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography.Biomedical optics express · 2019Article
- Spectroscopic photonic force optical coherence elastography.Optics letters · 2019Article
- Understanding the Stiff-to-Compliant Transition of the Meniscal Attachments by Spatial Correlation of Composition, Structure, and Mechanics.ACS applied materials & interfaces · 2019Article
- Does group velocity always reflect elastic modulus in shear wave elastography?Journal of biomedical optics · 2019Article
- Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography.Biomedical optics express · 2019Article
- Temporally and spatially adaptive Doppler analysis for robust handheld optical coherence elastography.Biomedical optics express · 2018Article
- Photonic force optical coherence elastography for three-dimensional mechanical microscopy.Nature communications · 2018Article
- Biomechanical assessment of myocardial infarction using optical coherence elastography.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We present an optical technique to image the frequency-dependent complex mechanical response of a viscoelastic sample. Three-dimensional hyperspectral data, comprising two-dimensional B-mode images and a third dimension corresponding to vibration frequency, were acquired from samples undergoing external mechanical excitation in the audio-frequency range. We describe the optical coherence tomography (OCT) signal when vibration is applied to a sample and detail the processing and acquisition techniques used to extract the local complex mechanical response from three-dimensional data that, due to a wide range of vibration frequencies, possess a wide range of sample velocities. We demonstrate frequency-dependent contrast of the displacement amplitude and phase of a silicone phantom containing inclusions of higher stiffness. Measurements of an ex vivo tumor margin demonstrate distinct spectra between adipose and tumor regions, and images of displacement amplitude and phase demonstrated spatially-resolved contrast. Contrast was also observed in displacement amplitude and phase images of a rat muscle sample. These results represent the first demonstration of mechanical spectroscopy based on B-mode OCT imaging. Spectroscopic optical coherence elastography (S-OCE) provides a high-resolution imaging capability for the detection of tissue pathologies that are characterized by a frequency-dependent viscoelastic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.