ArticleEMBO reports2011
Macrophages recognize streptococci through bacterial single-stranded RNA.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Time to rethink prevention of neonatal group B streptococcal disease.Seminars in immunopathology · 2026Review
- Role of endosomal toll-like receptors in immune sensing ofFrontiers in immunology · 2025Article
- Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis.JCI insight · 2024Article
- The RNA from Pseudomonas aeruginosa Reduces Neutrophil Responses Favoring Bacterial Survival.Journal of innate immunity · 2024Article
- Dysregulated monocyte-derived macrophage response to Group BFrontiers in immunology · 2023Article
- Temperature Influences the Composition and Cytotoxicity of Extracellular Vesicles in Staphylococcus aureus.mSphere · 2021Article
- Article
- Modeling MyD88 DeficiencyFrontiers in immunology · 2020Article
- Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense ofFrontiers in immunology · 2019Article
- The Toll Pathway in the Central Nervous System of Flies and Mammals.Neuromolecular medicine · 2018Review
- Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.Frontiers in pediatrics · 2018Review
- Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases.Frontiers in immunology · 2018Review
- Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.EMBO reports · 2017Article
- Intrinsic Maturational Neonatal Immune Deficiencies and Susceptibility to Group B Streptococcus Infection.Clinical microbiology reviews · 2017Review
- Identification of an optimized 2'-RNA (New York, N.Y.) · 2017Article
- Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease.Frontiers in immunology · 2017Review
- Toll-Like Receptor 8 Is a Major Sensor of Group BFrontiers in immunology · 2017Article
- TLR7 and TLR3 SenseFrontiers in immunology · 2017Article
- Bacterial RNA as a signal to eukaryotic cells as part of the infection process.Discoveries (Craiova, Romania) · 2016Review
- Lipoproteins of Gram-Positive Bacteria: Key Players in the Immune Response and Virulence.Microbiology and molecular biology reviews : MMBR · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Group B streptococcus (GBS) is a leading cause of both neonatal sepsis and meningitis, two diseases that are characterized by inflammation. However, the manner in which GBS organisms are recognized by monocytes and macrophages is poorly understood. In this study, we report that the recognition of GBS and other Gram-positive bacteria by macrophages and monocytes relies on bacterial single-stranded RNA (ssRNA). ssRNA interacts with a signalling complex, which comprises the Toll-like receptor adaptors MyD88 and UNC-93B, but not the established MyD88-dependent ssRNA sensors. The role of ssRNA in the recognition of Gram-positive bacteria--leading to the induction of inflammatory cytokines--has potential implications for sepsis pathogenesis, diagnosis and treatment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.