ReviewChannels (Austin, Tex.)
Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics?
Review in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?Biomolecules · 2023Review
- General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action.International journal of molecular sciences · 2022Review
- Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane.British journal of anaesthesia · 2021Article
- Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review.Frontiers in synaptic neuroscience · 2021Review
- Global genetic deletion of CaScientific reports · 2020Article
- Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system.Journal of neurophysiology · 2020Article
- The Effects of General Anesthetics on Synaptic Transmission.Current neuropharmacology · 2020Review
- Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.British journal of anaesthesia · 2019Article
- Influence of propofol on isolated neonatal rat carotid body glomus cell response to hypoxia and hypercapnia.Respiratory physiology & neurobiology · 2019Article
- A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.British journal of anaesthesia · 2018Article
- Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons.Frontiers in neural circuits · 2016Article
- Isoflurane causes concentration-dependent inhibition of medullary raphé 5-HT neurons in situ.Autonomic neuroscience : basic & clinical · 2015Article
- Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.Biophysical journal · 2015Review
- Article
- Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane.Neuropharmacology · 2012Article
- Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands.Molecular pain · 2011Article
- Article
- Signaling complexes of voltage-gated calcium channels.Channels (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The effects of anesthetics and analgesics on ion channels have been the subject of intense research since recent reports of direct actions of anesthetic molecules on ion channel proteins. It is now known that ligand-gated channels, particularly γ-amino-butyric acid (GABAA) and N-methyl-D-aspartate (NMDA) receptors, play a key role in mediating anesthetic actions, but these channels are unable to account for all aspects of clinical anesthesia such as loss of consciousness, immobility, analgesia, amnesia, and muscle relaxation. Furthermore, an assortment of voltage-gated and background channels also display anesthetic sensitivity and a key question arises: What role do these other channels play in clinical anesthesia? These channels have overlapping physiological roles and pharmacological profiles, making it difficult to assign aspects of the anesthetic state to individual channel types. Here, we will focus on the function of neuronal voltage-gated calcium channels in mediating the effects of general anesthetics.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.