ArticleProceedings of the National Academy of Sciences of the United States of America2011
Two RNA subunits and POT1a are components of Arabidopsis telomerase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 70 citations in OpenAlex.
- Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity.The Biochemical journal · 2025Review
- Plant telomere biology: The green solution to the end-replication problem.The Plant cell · 2022Article
- Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding.Frontiers in plant science · 2021Review
- tRNA ADENOSINE DEAMINASE 3 is required for telomere maintenance in Arabidopsis thaliana.Plant cell reports · 2020Article
- Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes.Biomolecules · 2020Review
- Origin, Diversity, and Evolution of Telomere Sequences in Plants.Frontiers in plant science · 2020Review
- Evolutionary and biochemical analyses reveal conservation of the Brassicaceae telomerase ribonucleoprotein complex.PloS one · 2020Article
- The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humans.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Telomerase RNAs in land plants.Nucleic acids research · 2019Article
- Review
- Opaque-2 Regulates a Complex Gene Network Associated with Cell Differentiation and Storage Functions of Maize Endosperm.The Plant cell · 2018Article
- Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis.Plant molecular biology · 2018Article
- Article
- DDM1 guards against telomere truncation in Arabidopsis.Plant cell reports · 2018Article
- The Long Intergenic Noncoding RNA (LincRNA) Landscape of the Soybean Genome.Plant physiology · 2018Article
- Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo.Protoplasma · 2017Article
- Protection of Arabidopsis Blunt-Ended Telomeres Is Mediated by a Physical Association with the Ku Heterodimer.The Plant cell · 2017Article
- Tissue-specific expression of telomerase reverse transcriptase gene variants in Nicotiana tabacum.Planta · 2017Article
- Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress.Oncotarget · 2016Article
- Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulation.Nucleic acids research · 2016Article
Corrections and comments
- Retraction · 2019-11-21Contamination of Materials · Error in Methods · Error in Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Telomerase is a ribonucleoprotein (RNP) reverse transcriptase whose essential RNA subunit (TER) functions as a template for telomere repeat synthesis. Here we report the identification of two divergent TER moieties in the flowering plant Arabidopsis thaliana. Although both TER1 and TER2 copurify with telomerase activity and serve as templates for telomerase in vitro, depletion of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening in vivo. Moreover, mutation of the templating domain in TER1 results in the incorporation of mutant telomere repeats on chromosome ends. Thus, TER1 provides the major template for telomerase in vivo. We also show that POT1a binds TER1 with a Kd of 2 × 10(-7) M and the two components assemble into an enzymatically active RNP in vivo. In contrast, TER1-POT1b and TER2-POT1a associations were not observed. In other organisms POT1 proteins bind telomeric DNA and provide chromosome end protection. We propose that duplication of TER and POT1 in Arabidopsis fueled the evolution of novel protein-nucleic acid interactions and the migration of POT1 from the telomere to the telomerase RNP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.