ArticleThe Journal of biological chemistry2011
Plasticity in membrane cholesterol contributes toward electrical maturation of hearing.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis.eLife · 2026Article
- Impact of cholesterol homeostasis within cochlear cells on auditory development and hearing loss.Frontiers in cellular neuroscience · 2023Review
- Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear.Journal of proteomics · 2014Article
- Microdomains shift and rotate in the lateral wall of cochlear outer hair cells.Biophysical journal · 2013Article
- A coregulatory network of NR2F1 and microRNA-140.PloS one · 2013Article
- Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-β-cyclodextrin.PloS one · 2012Article
- Effects of cholesterol on nano-mechanical properties of the living cell plasma membrane.Soft matter · 2012Article
- Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps.PLoS computational biology · 2012Article
- Cholesterol influences voltage-gated calcium channels and BK-type potassium channels in auditory hair cells.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Advances in refining the "fluid mosaic" model of the plasma membrane have revealed that it is wrought with an ordered lipid composition that undergoes remarkable plasticity during cell development. Despite the evidence that specific signaling proteins and ion channels gravitate toward these lipid microdomains, identification of their functional impact remains a formidable challenge. We report that in contrast to matured auditory hair cells, depletion of membrane cholesterol in developing hair cells produced marked potentiation of voltage-gated K(+) currents (I(Kv)). The enhanced magnitude of I(Kv) in developing hair cells was in keeping with the reduced cholesterol-rich microdomains in matured hair cells. Remarkably, potentiation of the cholesterol-sensitive current was sufficient to abolish spontaneous activity, a functional blueprint of developing and regenerating hair cells. Collectively, these findings provide evidence that developmental plasticity of lipid microdomains and the ensuing changes in K(+) currents are important determinants of one of the hallmarks in the maturation of hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.