ArticleCirculation. Arrhythmia and electrophysiology2011
Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia.
Article in Circulation. Arrhythmia and electrophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Proteomic Mechanisms of Hepatic- and Cardio-Protection of a Food-Hoarding Hibernator, Tamias sibiricus.Integrative zoology · 2026Article
- Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.Frontiers in physiology · 2025Article
- Cumulative Effects of Cannabis Oils on Body Temperature, Electrocardiography, Heart Rate Variability, Blood Pressure, and Respiratory Function in Telemetered Dogs.International journal of veterinary science and medicine · 2025Article
- Beneficial Effect of Calcium Treatment for Hyperkalemia Is Not Due to "Membrane Stabilization".Critical care medicine · 2024Article
- Spontaneous Repolarization Alternans Causes VT/VF Rearrest That Is Suppressed by Preserving Gap Junctions.JACC. Clinical electrophysiology · 2024Article
- Article
- Hypothermia-induced accelerated idioventricular rhythm after cardiac surgery; a case report.BMC cardiovascular disorders · 2023Article
- Myocardial electrophysiological and mechanical changes caused by moderate hypothermia-A clinical study.Physiological reports · 2022Article
- The goldfish Carassius auratus: an emerging animal model for comparative cardiac research.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Review
- Dynamic spatial dispersion of repolarization is present in regions critical for ischemic ventricular tachycardia ablation.Heart rhythm O2 · 2021Article
- Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation.Journal of the American Heart Association · 2021Article
- Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.Pflugers Archiv : European journal of physiology · 2021Review
- Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model.Frontiers in physiology · 2021Article
- Changes in left ventricular electromechanical relations during targeted hypothermia.Intensive care medicine experimental · 2020Article
- Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology.Cardiovascular research · 2020Article
- Excitation-Contraction Coupling in the Goldfish (Frontiers in physiology · 2020Article
- Electrocardiographic changes during therapeutic hypothermia: observational data from a single centre.Acta medica Lituanic · 2019Article
- Hypothermia Modulates Arrhythmia Substrates During Different Phases of Resuscitation From Ischemic Cardiac Arrest.Journal of the American Heart Association · 2017Article
- Hypothermia induced alteration of repolarization - impact on acute and long-term outcome: a prospective cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2017Article
- Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and NaAmerican journal of physiology. Heart and circulatory physiology · 2017Article
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5 authors.
Funding
Abstract
backgroundHypothermia is proarrhythmic, and, as the use of therapeutic hypothermia (TH) increases, it is critically important to understand the electrophysiological effects of hypothermia on cardiac myocytes and arrhythmia substrates. We tested the hypothesis that hypothermia-enhanced transmural dispersion of repolarization (DOR) is a mechanism of arrhythmogenesis in hypothermia. In addition, we investigated whether the degree of hypothermia, the rate of temperature change, and cooling versus rewarming would alter hypothermia-induced arrhythmia substrates. METHODS AND
resultsOptical action potentials were recorded from cells spanning the transmural wall of canine left ventricular wedge preparations at baseline (36°C), during cooling and during rewarming. Electrophysiological parameters were examined while varying the depth of hypothermia. On cooling to 26°C, DOR increased from 26±4 ms to 93±18 ms (P=0.021); conduction velocity decreased from 35±5 cm/s to 22±5 cm/s (P=0.010). On rewarming to 36°C, DOR remained prolonged, whereas conduction velocity returned to baseline. Conduction block and reentry was observed in all severe hypothermia preparations. Ventricular fibrillation/ventricular tachycardia was seen more during rewarming (4/5) versus cooling (2/6). In TH (n=7), cooling to 32°C mildly increased DOR (31±6 to 50±9, P=0.012), with return to baseline on rewarming and was associated with decreased arrhythmia susceptibility. Increased rate of cooling did not further enhance DOR or arrhythmogenesis.
conclusionsHypothermia amplifies DOR and is a mechanism for arrhythmogenesis. DOR is directly dependent on the depth of cooling and rewarming. This provides insight into the clinical observation of a low incidence of arrhythmias in TH and has implications for protocols for the clinical application of TH.
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