Evidence map›Paper›PMID 21163346›Full record

ReviewFree radical biology & medicine2011

Oxidative stress, insulin signaling, and diabetes.

Justin L Rains, Sushil K Jain

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 559 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
559citing papers in PubMed, 6 pooled it
30.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

559 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,414 citations in OpenAlex.

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  13. Association of serum element levels with cardiovascular diseases and type 2 diabetes mellitus risk in a Kurdish population of western Iran.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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499 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justin L RainsDepartment of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Sushil K Jain
Louisiana State University Health Sciences Center Shreveport · US

Funding

Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic PatientsR01DK072433 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI JAIN, SUSHIL K · 2007 to 2010
$1.3M
NIDDK NIH HHS R01 DK072433
6 · The paper itself

Abstract

Oxidative stress has been implicated as a contributor to both the onset and the progression of diabetes and its associated complications. Some of the consequences of an oxidative environment are the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance, and mitochondrial dysfunction, which can lead ultimately to the diabetic disease state. Experimental and clinical data suggest an inverse association between insulin sensitivity and ROS levels. Oxidative stress can arise from a number of different sources, whether disease state or lifestyle, including episodes of ketosis, sleep restriction, and excessive nutrient intake. Oxidative stress activates a series of stress pathways involving a family of serine/threonine kinases, which in turn have a negative effect on insulin signaling. More experimental evidence is needed to pinpoint the mechanisms contributing to insulin resistance in both type 1 diabetics and nondiabetic individuals. Oxidative stress can be reduced by controlling hyperglycemia and calorie intake. Overall, this review outlines various mechanisms that lead to the development of oxidative stress. Intervention and therapy that alter or disrupt these mechanisms may serve to reduce the risk of insulin resistance and the development of diabetes.

Indexed as

Insulin ResistanceAmino AcidsAntioxidantsChromiumDiabetes MellitusDiabetic KetoacidosisEnergy IntakeHumansHyperglycemiaInsulinMitochondriaNicotinic AcidsOxidative StressProtein Serine-Threonine KinasesPTEN PhosphohydrolaseReactive Oxygen SpeciesAmino AcidsAntioxidantsChromiumglucose tolerance factorInsulinNicotinic AcidsProtein Serine-Threonine KinasesPTEN PhosphohydrolasePTEN protein, humanReactive Oxygen Species

Identifiers

PMID21163346
PMCPMC3557825
OpenAlexW2064483915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.