ArticleNeuroscience2011
Direct projections from the caudal vestibular nuclei to the ventrolateral medulla in the rat.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons.Circulation research · 2026Article
- Otolith Irregular Fiber Stimulation Elicits a Rostro-Caudal Activity Gradient in the Vestibular Nuclear Complex and Both Direct and Indirect Afferent Pathways of the Vestibulocerebellum.The Journal of comparative neurology · 2025Article
- Update on Clinical Physiology and Pathomechanisms for Vestibulo-Autonomic Interplay.Cerebellum (London, England) · 2025Review
- Ocular Vestibular-Evoked Myogenic Potential Assists in the Differentiation of Multiple System Atrophy From Parkinson's Disease.Journal of movement disorders · 2024Article
- Augmented ocular vestibular-evoked myogenic potentials in postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Utricular dysfunction in patients with orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.Frontiers in neurology · 2021Article
- VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice.Communications biology · 2020Article
- Responses of neurons in the rostral ventrolateral medulla of conscious cats to anticipated and passive movements.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Responses of Neurons in the Medullary Lateral Tegmental Field and Nucleus Tractus Solitarius to Vestibular Stimuli in Conscious Felines.Frontiers in neurology · 2020Article
- Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex.The journal of physiological sciences : JPS · 2019Article
- Vestibular neurons with direct projections to the solitary nucleus in the rat.Journal of neurophysiology · 2019Article
- Role of peripheral vestibular receptors in the control of blood pressure following hypotension.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Review
- Full Spectrum of Reported Symptoms of Bilateral Vestibulopathy Needs Further Investigation-A Systematic Review.Frontiers in neurology · 2018Article
- Dual control of the vestibulosympathetic reflex following hypotension in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
- Descending Influences on Vestibulospinal and Vestibulosympathetic Reflexes.Frontiers in neurology · 2017Review
- Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice.Brain structure & function · 2016Article
- Imidazoleacetic acid-ribotide in vestibulo-sympathetic pathway neurons.Experimental brain research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
While the basic pathways mediating vestibulo-ocular, -spinal, and -collic reflexes have been described in detail, little is known about vestibular projections to central autonomic sites. Previous studies have primarily focused on projections from the caudal vestibular region to solitary, vagal and parabrachial nuclei, but have noted a sparse innervation of the ventrolateral medulla. Since a direct pathway from the vestibular nuclei to the rostral ventrolateral medulla would provide a morphological substrate for rapid modifications in blood pressure, heart rate and respiration with changes in posture and locomotion, the present study examined anatomical evidence for this pathway using anterograde and retrograde tract tracing and immunofluorescence detection in brainstem sections of the rat medulla. The results provide anatomical evidence for direct pathways from the caudal vestibular nuclear complex to the rostral and caudal ventrolateral medullary regions. The projections are conveyed by fine and highly varicose axons that ramify bilaterally, with greater terminal densities present ipsilateral to the injection site and more rostrally in the ventrolateral medulla. In the rostral ventrolateral medulla, these processes are highly branched and extremely varicose, primarily directed toward the somata and proximal dendrites of non-catecholaminergic neurons, with minor projections to the distal dendrites of catecholaminergic cells. In the caudal ventrolateral medulla, the axons of vestibular nucleus neurons are more modestly branched with fewer varicosities, and their endings are contiguous with both the perikarya and dendrites of catecholamine-containing neurons. These data suggest that vestibular neurons preferentially target the rostral ventrolateral medulla, and can thereby provide a morphological basis for a short latency vestibulo-sympathetic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.