ArticleBMC evolutionary biology2010
Differential regulation drives plasticity in sex determination gene networks.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- Antagonistic Coevolution Drives Whack-a-Mole Sensitivity in Gene Regulatory Networks.PLoS computational biology · 2015Article
- Patterns and mechanisms of evolutionary transitions between genetic sex-determining systems.Cold Spring Harbor perspectives in biology · 2014Review
- Molecular evolution of Drosophila Sex-lethal and related sex determining genes.BMC evolutionary biology · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
backgroundSex determination networks evolve rapidly and have been studied intensely across many species, particularly in insects, thus presenting good models to study the evolutionary plasticity of gene networks.
resultsWe study the evolution of an unlinked gene capable of regulating an existing diploid sex determination system. Differential gene expression determines phenotypic sex and fitness, dramatically reducing the number of assumptions of previous models. It allows us to make a quantitative evaluation of the full range of evolutionary outcomes of the system and an assessment of the likely contribution of sexual conflict to change in sex determination systems. Our results show under what conditions network mutations causing differential regulation can lead to the reshaping of sex determination networks.
conclusionThe analysis demonstrates the complex relationship between mutation and outcome: the same mutation can produce many different evolved populations, while the same evolved population can be produced by many different mutations. Existing network structure alters the constraints and frequency of evolutionary changes, which include the recruitment of new regulators, changes in heterogamety, protected polymorphisms, and transitions to a new locus that controls sex determination.
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