Evidence map›Paper›PMID 21161696›Full record

ReviewImmunologic research2011

Immunologic aspects of monoclonal B-cell lymphocytosis.

Mark C Lanasa, J Brice Weinberg

Abstract readReview
In one paragraph

Review in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark C LanasaDepartment of Medicine, Duke University Medical Center, Box 3872, 1 Trent Drive, Morris Building Room 25153, Durham, NC 27710, USA. mark.lanasa@duke.edu
J Brice Weinberg
Duke University · USDuke University Hospital · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Duke University Center for Translational ResearchP30AI051445 · NIAID · DUKE UNIVERSITY · PI FROTHINGHAM, RICHARD · 2002 to 2006
$8.1M
Genetic Epidemiology of Chronic Lymphocytic LeukemiaU01CA118444 · NCI · MAYO CLINIC ROCHESTER · PI SLAGER, SUSAN L · 2006 to 2015
$7.1M
Molecular Epidemiology of NHL and CLLR01CA092153 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R · 2003 to 2012
$6.7M
Prevention of Chronic Lymphocytic Leukemia (CLL)R03CA128030 · NCI · DUKE UNIVERSITY · PI LEVESQUE, MARC C. · 2007 to 2008
$156k
Intramural NIH HHSNCI NIH HHS CA118444NCI NIH HHS CA92153NCI NIH HHS N01 CA015083NCI NIH HHS P30 CA015083NCI NIH HHS R01 CA092153NCI NIH HHS R03 CA128030NCI NIH HHS U01 CA118444NCRR NIH HHS 1 UL1 RR024150NCRR NIH HHS UL1 RR024150NIAID NIH HHS AI-51445NIAID NIH HHS P30 AI051445
6 · The paper itself

Abstract

Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic condition wherein small numbers of clonal B cells can be detected in the blood of otherwise healthy individuals. Most MBL have a surface immunophenotype nearly identical to that of chronic lymphocytic leukemia (CLL), though other phenotypes can also be identified. MBL has been shown to be a precursor state for CLL, but most MBL clones are quite small and apparently have minimal potential to progress of CLL or other B-cell lymphoproliferative disorder (B-LPD). The investigation of MBL as a precursor state for CLL will likely lead to important insights into mechanisms of disease pathogenesis. The review will cover clinical and translational aspects of MBL, with a particular emphasis on the prevalence of MBL; the relationship between MBL, CLL, and other B-LPDs; and the capacity of MBL to modulate the normal B- and T-cell compartments.

Indexed as

B-LymphocytesHumansLeukemia, Lymphocytic, Chronic, B-CellLymphocytosisPolymorphism, Single NucleotideReceptors, Antigen, B-CellT-LymphocytesReceptors, Antigen, B-Cell

Identifiers

PMID21161696
PMCPMC4102133
OpenAlexW2032972885

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.