ReviewThe Journal of membrane biology2011
The alternating access transport mechanism in LacY.
Review in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed.
- Intrinsic Asymmetry in Weak Acid Transmembrane Transporters.Biomolecules · 2026Review
- Structural and biochemical insights of xylose MFS and SWEET transporters in microbial cell factories: challenges to lignocellulosic hydrolysates fermentation.Frontiers in microbiology · 2024Review
- Lactose Permease Scrambles Phospholipids.Biology · 2023Article
- Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1.Nature communications · 2023Article
- Structure-Based Function and Regulation of NCX Variants: Updates and Challenges.International journal of molecular sciences · 2022Review
- Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting.Tissue barriers · 2022Review
- General principles of secondary active transporter function.Biophysics reviews · 2022Review
- The Bul1/2 Alpha-Arrestins Promote Ubiquitylation and Endocytosis of the Can1 Permease upon Cycloheximide-Induced TORC1-Hyperactivation.International journal of molecular sciences · 2021Article
- Integrating Membrane Transporter Proteins into Droplet Interface Bilayers.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters.Journal of molecular biology · 2020Article
- Plant glucose transporter structure and function.Pflugers Archiv : European journal of physiology · 2020Review
- Life and Death of Fungal Transporters under the Challenge of Polarity.International journal of molecular sciences · 2020Review
- It takes two to tango: The dance of the permease.The Journal of general physiology · 2019Review
- Tales of tails in transporters.Open biology · 2019Review
- Phylogenetic and conservation analyses of MFS transporters.3 Biotech · 2018Article
- Structural basis for amino acid transport by the CAT family of SLC7 transporters.Nature communications · 2018Article
- Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.Molecular pharmaceutics · 2017Article
- Substrate Specificity of the FurE Transporter Is Determined by Cytoplasmic Terminal Domain Interactions.Genetics · 2017Article
- Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae.Scientific reports · 2017Article
- Correlation between Apparent Substrate Affinity and OCT2 Transport Turnover.The Journal of pharmacology and experimental therapeutics · 2017Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Lactose permease of Escherichia coli (LacY) is highly dynamic, and sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport via LacY very likely involves a global conformational change that allows alternating access of single sugar- and H(+)-binding sites to either side of the membrane. Here, in honor of Stephan H. White's seventieth birthday, we review in camera the various biochemical/biophysical approaches that provide experimental evidence for the alternating access mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.