Evidence map›Paper›PMID 21161400›Full record

ArticleMolecular biology reports2011

Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.

Jinling Xiao, Jianyu Han, Xinyan Wang, Demi Hua, Dongju Su, Yongxia Bao, Fuzhen Lv

Abstract read
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In one paragraph

Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genetic polymorphism and chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017
    Review
  7. Gene polymorphisms and chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2014
    Article
  8. Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-β.American journal of respiratory cell and molecular biology · 2012
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jinling XiaoDepartment of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. xiaojinlingxiao@yahoo.com.cn
Jianyu Han
Xinyan Wang
Demi Hua
Dongju Su
Yongxia Bao
Fuzhen Lv
Second Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNXian Yang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality, influenced by both environmental factor and genetic factor. ADAM33 gene was found to be associated with asthma, declined lung function and COPD. The purpose of the study was to test whether SNPs in ADAM33 were associated with COPD in Tibetan population of China. Polymerase chain reaction-restriction fragment length polymorphism was carried out to genotype the eight SNPs (V4, T2, T1, S2, S1, Q-1 and F + 1) of ADAM33 on 240 COPD patients and 221 healthy individuals. Four SNPs (V4, T2, T1 and S1) and four haplotypes (H2 CGAAGAGC, H5 GAGAGAGC, H9 GAAAGAGC and H6 CGGGGAGC of ADAM33 gene were associated with COPD significantly (defined as P < 0.05). The results indicate that there is an association between ADAM33 polymorphisms and COPD in Tibetan population of China.

Indexed as

Genetic Predisposition to DiseaseADAM ProteinsAllelesBase SequenceFemaleGene FrequencyGenetics, PopulationHaplotypesHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveTibetADAM33 protein, humanADAM Proteins

Identifiers

PMID21161400
OpenAlexW1994489347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.