Evidence map›Paper›PMID 21161263›Full record

Trial reportEuropean journal of applied physiology2011

Effects of limb posture on reactive hyperemia.

Anandi Krishnan, Elisabeth B Lucassen, Cindy Hogeman, Cheryl Blaha, Urs A Leuenberger

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Autonomic cardiovascular changes during reactive hyperemia.Clinical physiology and functional imaging · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anandi KrishnanPenn State Heart and Vascular Institute, H047, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, PO Box 850, Hershey, PA 17033, USA.
Elisabeth B Lucassen
Cindy Hogeman
Cheryl Blaha
Urs A Leuenberger
Penn State Milton S. Hershey Medical Center · US

Funding

WRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DONG, CHENG · 1995 to 2009
$29.8M
Sympathetic/Cardiopulmonary Regulation by Vestibular RefP01HL077670 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2004 to 2008
$6.9M
Extramural Research Facilities Improvement Program "Dru*C06RR020578 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PAZ, HAROLD L. · 2010 to 2010
$2.8M
Sympathetic and Vascular Function in Sleep ApneaR01HL068699 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEUENBERGER, URS A · 2003 to 2006
$1.0M
GCRC RELOCATION AND EXPANSION PROJECTC06RR016499 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIRCH, DARRELL G · 2001 to 2001
$707k
NCRR NIH HHS C06 RR016499NCRR NIH HHS C06 RR020578NCRR NIH HHS M01 RR010732NHLBI NIH HHS P01 HL077670NHLBI NIH HHS R01 HL068699
6 · The paper itself

Abstract

To examine the role of limb posture on vascular conductance during rapid changes in vascular transmural pressure, we determined brachial (n = 10) and femoral (n = 10) artery post-occlusive reactive hyperemic blood flow (RHBF, ultrasound/Doppler) and vascular conductance in healthy humans with each limb at three different positions-horizontal, up and down. Limb posture was varied by raising or lowering the arm or leg from the horizontal position by 45°. In both limbs, peak RHBF and vascular conductance were highest in the down or horizontal position and lowest in the up position (arm up 338 ± 38, supine 430 ± 52, down 415 ± 52 ml/min, P < 0.05; leg up 1,208 ± 88, supine 1,579 ± 130, down 1,767 ± 149 ml/min, P < 0.05). In contrast, the maximal dynamic fall in blood flow following peak RHBF (in ml/s/s) in both limbs was highest in the limb-down position and lowest with the limb elevated (P < 0.05). These data suggest that the magnitude and temporal pattern of limb reactive hyperemia is in part related to changes in vascular transmural pressure and independent of systemic blood pressure and sympathetic control.

Indexed as

AdultArmBlood PressureExtremitiesFemaleHeart RateHumansHyperemiaLegMalePostureRegional Blood FlowVascular ResistanceYoung Adult

Identifiers

PMID21161263
PMCPMC3285391
OpenAlexW2051144064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.