ArticleWorld journal of hepatology2010
Physiopathology of splanchnic vasodilation in portal hypertension.
Article in World journal of hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 127 citations in OpenAlex.
- Portal Vein Thrombosis Risk in Cirrhotic Patients With Portal Hypertension on Beta-Blockers: A Multi-Institutional Cohort Study.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Sustained effectiveness of balloon-occluded retrograde transvenous obliteration for portopulmonary hypertension after liver transplantation: a 5-year follow-up case report.Clinical journal of gastroenterology · 2025Article
- Isolation and immortalization of human portal vein endothelial cells: A novel research tool for studying splanchnic vasculature.JHEP reports : innovation in hepatology · 2025Article
- Predictive model of in-hospital mortality in liver cirrhosis patients with hyponatremia: an artificial neural network approach.Scientific reports · 2024Article
- Review
- The Renin-Angiotensin System in Liver Disease.International journal of molecular sciences · 2024Review
- Recent developments in the management of ascites in cirrhosis.United European gastroenterology journal · 2024Review
- Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis-Pathogenesis, Implications and Therapeutic Opportunities.Nutrients · 2023Review
- Evidence-based hyponatremia management in liver disease.Clinical and molecular hepatology · 2023Review
- Oxidative stress triggers hyperdynamic circulation via central neural activation in portal hypertensive rats.Hepatology international · 2023Article
- Use of Human Albumin Administration for the Prevention and Treatment of Hyponatremia in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Article
- Incidental finding of elevated pulmonary arterial pressures during liver transplantation and postoperative pulmonary complications.BMC anesthesiology · 2022Article
- Cardiac risk stratification of the liver transplant candidate: A comprehensive review.World journal of transplantation · 2022Review
- Synergistic antioxidant and anti-inflammatory action of N-acetylcysteine in portal hypertensive gastropathy in rats.Hepatology forum · 2022Article
- Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score.JHEP reports : innovation in hepatology · 2022Article
- Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury.BMC nephrology · 2022Article
- Prognostic value of blood pressure and resting heart rate in patients with tricuspid regurgitation.Frontiers in cardiovascular medicine · 2022Article
- Current and investigational drugs in early clinical development for portal hypertension.Frontiers in medicine · 2022Review
- Hepatic perfusion as a new predictor of prognosis and mortality in critical care patients with acute-on-chronic liver failure.Frontiers in medicine · 2022Article
- Critically Ill COVID-19 Patient with Chronic Liver Disease - Insights into a Comprehensive Liver Intensive Care.Journal of clinical and translational hepatology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In liver cirrhosis, the circulatory hemodynamic alterations of portal hypertension significantly contribute to many of the clinical manifestations of the disease. In the physiopathology of this vascular alteration, mesenteric splanchnic vasodilation plays an essential role by initiating the hemodynamic process. Numerous studies performed in cirrhotic patients and animal models have shown that this splanchnic vasodilation is the result of an important increase in local and systemic vasodilators and the presence of a splanchnic vascular hyporesponsiveness to vasoconstrictors. Among the molecules and factors known to be potentially involved in this arterial vasodilation, nitric oxide seems to have a crucial role in the physiopathology of this vascular alteration. However, none of the wide variety of mediators can be described as solely responsible, since this phenomenon is multifactorial in origin. Moreover, angiogenesis and vascular remodeling processes also seem to play a role. Finally, the sympathetic nervous system is thought to be involved in the pathogenesis of the hyperdynamic circulation associated with portal hypertension, although the nature and extent of its role is not completely understood. In this review, we discuss the different mechanisms known to contribute to this complex phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.