Evidence map›Paper›PMID 21160971›Full record

ArticleWorld journal of hepatology2009

Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice.

Hirayuki Enomoto, Hideji Nakamura, Naoko Komatsu-Kanatani, Yu Liu, Kenya Yoshida, Yorihide Okuda, Teruhisa Yamamoto, Weidong Liu, Shuhei Nishiguchi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Hirayuki EnomotoHirayuki Enomoto, Hideji Nakamura, Teruhisa Yamamoto, Weidong Liu, Shuhei Nishiguchi, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Hideji Nakamura
Naoko Komatsu-Kanatani
Yu Liu
Kenya Yoshida
Yorihide Okuda
Teruhisa Yamamoto
Weidong Liu
Shuhei Nishiguchi
Osaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the role of hepatoma-derived growth factor (HDGF) in liver development, especially in the hepatocyte differentiation.

methodsWe generated transgenic mice which overexpressed HDGF in hepatocytes under the transcriptional control of mouse albumin promoter/enhancer. To examine the effects of HDGF overexpression on hepatocyte differentiation, we investigated the expression patterns of the differentiation marker genes.

resultsThe HDGF transgenic mice developed normally and showed no apparent abnormality in the liver. However, the gene expression patterns of the liver in adult transgenic mice were similar to those of the neonatal liver in control mice.

conclusionThese findings suggest that HDGF-overexpression partially suppresses hepatocyte maturation.

Indexed as

HepatocyteHepatoma-derived growth factorMaturationTransgenic mice

Identifiers

PMID21160971
PMCPMC2999260
OpenAlexW2328166953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.