Evidence map›Paper›PMID 21160926›Full record

ArticleWorld journal of gastrointestinal oncology2010

Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer.

Yutaka Yonemura, Ayman Elnemr, Yoshio Endou, Mitsumasa Hirano, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Masahiro Miura, Yan Li

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04522011 unknown statusnot on this mapstarted 2021, after this paper: background citation

Comparison of the Efficiency Between Intraoperative and Postoperative Hyperthermic Intraperitoneal Chemotherapy With Docetaxel Combine Oxaliplatin in Patients With Advanced Gastric Cancer

TypeobservationalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2021 to 2023Enrolled200ConditionsStomach Neoplasms, Hyperthermic Intraperitoneal ChemotherapyArmsintraoperative or postoperative hyperthermic intraperitoneal chemotherapy
NCT04752930 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Circulating Tumor DNA (ctDNA) as a Assisted Diagnosis, Early Intervention and Prognostic Marker for Peritoneal Metastases From Colorectal Cancer: A Prospective, Open-label, Randomized Controlled Study

TypeinterventionalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2020 to 2025Enrolled138ConditionsColorectal Cancer, Peritoneal MetastasesArmsctDNA monitoring, Imageology
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 147 citations in OpenAlex.

  1. Review
  2. Review
  3. Gastric cancer with limited peritoneal metastasis: Role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape : Bertinoro Workshop, November 2022.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Hyperthermic Intraperitoneal Chemotherapy in the Management of Gastric Cancer: A Narrative Review.International journal of environmental research and public health · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yutaka YonemuraYutaka Yonemura, Ayman Elnemr, NPO Organization to Support Peritoneal Dissemination Treatment, Kishiwada, Osaka 596-0032, Japan.
Ayman Elnemr
Yoshio Endou
Mitsumasa Hirano
Akiyoshi Mizumoto
Nobuyuki Takao
Masumi Ichinose
Masahiro Miura
Yan Li

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer. A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)], peritonectomy, hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been developed. In this article, we assess the indications, safety and efficacy of this treatment, review the relevant studies and introduce our experiences. The aims of NIPS are stage reduction, the eradication of peritoneal free cancer cells, and an increased incidence of complete cytoreduction (CC-0) for PC. A complete response after NIPS was obtained in 15 (50%) out of 30 patients with PC. Thus, a significantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ 6. Using a multivariate analysis to examine the survival benefit, CC-0 and NIPS are identified as significant indicators of a good outcome. However, the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection important. The best indications for multidisciplinary therapy are localized PC (PCI ≤ 6) from resectable gastric cancer that can be completely removed during a peritonectomy. NIPS and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer.

Indexed as

ChemotherapyGastric cancerPeritoneal carcinomatosis

Identifiers

PMID21160926
PMCPMC2998933
OpenAlexW2004576106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.