ArticleWorld journal of gastrointestinal surgery2010
Treatment of colorectal carcinoids: A new paradigm.
Article in World journal of gastrointestinal surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Prognostic role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with midgut neuroendocrine tumors undergoing resective surgery.International journal of colorectal disease · 2019Article
- A well differentiated neuroendocrine tumor of the jejunum with peritoneal carcinomatosis: A case report.Molecular and clinical oncology · 2018Article
- Is there any role for minimally invasive surgery in NET?Reviews in endocrine & metabolic disorders · 2017Review
- Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study.BMC cancer · 2017Article
- Early Gastroenteropancreatic Neuroendocrine Tumors: Endoscopic Therapy and Surveillance.Visceral medicine · 2017Review
- Evaluation of treatment for rectal neuroendocrine tumors sized under 20 mm in comparison with the WHO 2010 guidelines.Molecular and clinical oncology · 2017Article
- Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from well-differentiated neuroendocrine tumour and poorly-differentiated adenocarcinomas.European radiology · 2017Article
- Recurrence 30 Years after Surgical Resection of a Localized Rectal Neuroendocrine Tumor.Internal medicine (Tokyo, Japan) · 2017Article
- The Ki-67 labeling index and lymphatic/venous permeation predict the metastatic potential of rectal neuroendocrine tumors.Surgical endoscopy · 2016Article
- Long-Term Clinical Outcomes of Rectal Neuroendocrine Tumors According to the Pathologic Status After Initial Endoscopic Resection: A KASID Multicenter Study.The American journal of gastroenterology · 2016Article
- Nonlinear optical microscopy for label-free detection of gastrointestinal neuroendocrine tumors.Lasers in medical science · 2016Article
- Long-term outcome of patients with locally resected high- and low-risk rectal carcinoid tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
- [Surgical management of a retrorectal tumor with consideration of a rare differential diagnosis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Article
- Management of early gastrointestinal neuroendocrine neoplasms.World journal of gastrointestinal endoscopy · 2011Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids.
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